A re-examination of the metabolic equivalent concept in individuals with coronary heart disease.
A re-examination of the metabolic equivalent concept in individuals with coronary heart disease.
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重新审视冠心病患者的代谢当量概念。
DOI：
10.1097/01.hcr.0000270693.16882.d9
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发表时间：
2007
影响因子：
3.8
通讯作者：
Ades,PhilipA
中科院分区：
文献类型：
--
作者：
Savage,PatrickD;Toth,MichaelJ;Ades,PhilipA
目的：代谢当量（MET）是量化能量消耗和体力活动强度的常用方法。最近的研究对广为接受的 3.5 mL O 2· kg− 1· min− 1 MET 值的准确性提出了质疑。本研究的目的是将传统上接受的 1 MET 值与一组稳定的冠心病 (CHD) 个体静息代谢率的直接测量值进行比较。 方法：主要队列由 109 名受试者（60 名男性和 49 名女性）组成，患有冠心病且体重指数≥ 25 kg/m 2。测量包括间接热量测定、身体成分和运动能力（峰值摄氧量 [VO 2]）。在一项由 17 名（10 名男性，7 名女性）正常体重受试者（体重指数 < 25 kg/m 2）组成的子研究中，还测量了坐位的代谢率。 结果：1 MET 的平均静息值为 VO 2 值，超重受试者仰卧位测量的 VO 2 值为 2.58±0.4 mL O 2· kg− 1· min− 1，超重受试者的 VO 2 值为 2.84±0.59 mL O 2· kg− 1· min− 1 对于正常体重的人，以坐姿测量。热量消耗值为0.74±0.12 kcal·kg−1·h−1，而不是预期值1 kcal·kg−1·h−1。男女之间的值相似。服用β受体阻滞剂的女性比未服用β受体阻滞剂的女性的静息代谢率较低（2.47±0.27 vs. 2.71±0.38 mL O 2·kg−1·min−1）（P<.05），而β受体阻滞剂对男性没有影响。结论：研究结果证实了最近对其他健康个体的研究，并表明冠心病受试者的平均静息代谢率为23%比广泛接受的 3.5 mL O 2· kg− 1· min− 1 值低 36%。结果表明，以假设常数的倍数表示能量消耗的惯例存在局限性。
OBJECTIVE:The metabolic equivalent (MET) is a commonly used method of quantifying the energy cost and intensity of physical activity. Recent studies have questioned the accuracy of the well-accepted value of a MET of 3.5 mL O 2· kg− 1· min− 1. The goal of the present study was to compare the traditionally accepted value for 1 MET to direct measures of resting metabolic rate in a group of stable individuals with coronary heart disease (CHD).METHODS:The primary cohort consisted of 109 (60 men and 49 women) subjects with documented coronary heart disease and a body mass index≥ 25 kg/m 2. Measurements included indirect calorimetry, body composition, and exercise capacity (peak oxygen uptake [VO 2]). In a substudy of 17 (10 men, 7 women) normal weight subjects (body mass index< 25 kg/m 2), metabolic rate in the seated position was also measured.RESULTS:Mean resting value for 1 MET was a VO 2 value of 2.58±0.4 mL O 2· kg− 1· min− 1 for overweight subjects measured in the supine position and 2.84±0.59 mL O 2· kg− 1· min− 1 for normal weight individuals measured in the seated position. Caloric expenditure value was 0.74±0.12 kcal· kg− 1· h− 1 rather than the expected value of 1 kcal· kg− 1· h− 1. Values were similar between men and women. Women on beta-blockers had a lower resting metabolic rate (2.47±0.27 vs. 2.71±0.38 mL O 2· kg− 1· min− 1)(P<. 05) than women not on beta-blocker therapy, whereas there was no effect of beta-blockers in men.CONCLUSIONS:Findings confirm recent studies of otherwise healthy individuals and indicate that the average resting metabolic rate in subjects with coronary heart disease is 23% to 36% lower than the widely accepted value of 3.5 mL O 2· kg− 1· min− 1. Results demonstrate the limitation of the convention of expressing energy expenditure in multiples of an assumed constant.