Event-related functional MRI: Past, present, and future
Event-related functional MRI: Past, present, and future
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DOI：
10.1073/pnas.95.3.773
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发表时间：
1998-02-03
影响因子：
11.1
通讯作者：
Dale, AM
中科院分区：
文献类型：
--
作者：
Rosen, BR;Buckner, RL;Dale, AM
在过去的二十年里，人类大脑绘图领域取得了巨大的发展，研究人员广泛利用正电子发射断层扫描和核磁共振成像等技术，根据脑血流动力学的变化来绘制大脑活动模式。然而，直到最近，大多数研究都调查了在 1 分钟以上的时间段内测量的血流平衡变化。高速 MRI 方法的出现，能够以几秒的时间分辨率对整个大脑进行成像，允许基于血流动力学响应的更瞬态方面进行脑图绘制。今天，现在可以基本上实时绘制脑血管参数的变化，从而能够观察数秒时间内发生的脑状态变化。此外，因为在神经元刺激仅持续几十毫秒，现在可以研究一类新的任务范式，旨在测量对单一感觉或认知事件的区域反应。这种“事件相关”的功能性磁共振成像应该提供询问大脑功能的全新方法，并允许直接比较和最终整合通过使用更传统的行为和电生理学方法获得的数据。
The past two decades have seen an enormous growth in the field of human brain mapping, Investigators have extensively exploited techniques such as positron emission tomography and MRI to map patterns of brain activity based on changes in cerebral hemodynamics. However, until recently, most studies have investigated equilibrium changes in blood flow measured over time periods upward of 1 min, The advent of high-speed MRI methods, capable of imaging the entire brain with a temporal resolution of a few seconds, allows for brain mapping based on more transient aspects of the hemodynamic response, Today it is now possible to map changes in cerebrovascular parameters essentially in real time, conferring the ability to observe changes in brain state that occur over time periods of seconds, Furthermore, because robust hemodynamic alterations are detectable after neuronal stimuli lasting only a few tens of milliseconds, a new class of task paradigms designed to measure regional responses to single sensory or cognitive events can now be studied, Such "event related" functional MRI should provide for fundamentally new ways to interrogate brain function, and allow for the direct comparison and ultimately integration of data acquired by using more traditional behavioral and electrophysiological methods.