Lichen sclerosus of the oral cavity. Case report and review of literature.
Lichen sclerosus of the oral cavity. Case report and review of literature.
复制标题
口腔硬化性苔藓。
DOI：
10.3315/jdcr.2010.1052
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
C. Thiruvenkadam
中科院分区：
文献类型：
--
作者：
H. Sherlin;K. Ramalingam;A. Natesan;P. Ramani;P. Premkumar;C. Thiruvenkadam
背景
硬化性苔藓是一种病因不明的慢性黏膜-皮肤炎性疾病。硬化性苔藓仅影响口腔黏膜的发病率非常罕见，仅有26例经组织学证实的口腔硬化性苔藓病例被报告。
主要观察结果
一位60岁男性因口腔白色病变而转诊至本院，此病无任何症状，亦无任何皮肤或肛门病变。临床检查显示双侧颊粘膜和上颌后牙龈有白色斑块和微红色区域。光镜下可见萎缩的上皮细胞，基底细胞变性，透明结缔组织间质，少量慢性炎症细胞浸润。Verhoff‘s染色显示结缔组织间质中弹性纤维稀少。根据这些组织学发现，最终诊断为硬化性苔藓。LS在口腔中很少见，特别是在没有同时发生皮肤和肛门病变的情况下。
结论
仅有7例口腔LS涉及牙龈的报道。据我们所知，这是第八例报告的牙龈受累病例，也是第一例双侧颊粘膜和牙龈受累的病例。
BACKGROUND
Lichen sclerosus is a chronic muco-cutaneous inflammatory disorder of uncertain etiology. The prevalence of lichen sclerosus affecting only the oral mucosa is extremely rare and only 26 cases with histologically verified oral lichen sclerosus have been reported.
MAIN OBSERVATIONS
A 60-year-old man was referred to our hospital for complaints of white lesions in the oral cavity, which was otherwise asymptomatic and did not have any cutaneous or anogenital lesions. Clinical examination revealed white patches with reddish areas on the buccal mucosa bilaterally and on the maxillary posterior gingiva. Microscopic analysis of the lesion showed atrophied epithelium with basal cell degeneration, hyalinized connective tissue stroma with minimal chronic inflammatory cell infiltrate. Verhoeff's staining revealed scantiness of elastic fibers in the connective tissue stroma. On the basis of these histological findings, the final diagnosis was given as Lichen Sclerosus. LS is rare in the oral cavity, particularly in the absence of simultaneous cutaneous and anogenital lesions.
CONCLUSIONS
Only 7 cases of oral LS have been reported involving the gingiva. To our knowledge, this is the eigth case to be reported with gingival involvement and the first case to be reported with bilateral involvement of buccal mucosa and gingiva.