Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update.
Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update.
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DOI：
10.1155/2012/978930
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发表时间：
2012
影响因子：
1.8
通讯作者：
Zheng T
中科院分区：
文献类型：
--
作者：
Bassig BA;Lan Q;Rothman N;Zhang Y;Zheng T
非霍奇金淋巴瘤(NHL)在美国的发病率在过去几十年里一直在稳步上升，发病率的时间趋势只能部分解释艾滋病毒的流行。1992年，由美国国家癌症研究所主办的一个国际研讨会得出结论，非霍奇金淋巴瘤出现了一种“新的流行病”，并强调有必要调查导致这种疾病发病率上升的因素。在过去的二十年里，大量的流行病学研究研究了非霍奇金淋巴瘤的危险因素，特别是假定的环境和生活方式危险因素，并建立了国际联盟，以调查罕见的暴露和非霍奇金淋巴瘤亚型之间的联系。虽然除了免疫抑制和某些感染性因素之外，几乎没有出现一致的NHL危险因素，但在流行病学研究中，已经报道了几种生活方式和环境因素与NHL的关联。此外，越来越多的证据表明，这些和其他暴露的影响可能限于或更强于特定的非霍奇金淋巴瘤亚型。本文回顾了过去二十年来在阐明非霍奇金淋巴瘤病因方面所取得的进展，主要侧重于生活方式因素和环境暴露。
The incidence rates of non-Hodgkin lymphoma (NHL) have steadily increased over the last several decades in the United States, and the temporal trends in incidence can only be partially explained by the HIV epidemic. In 1992, an international workshop sponsored by the United States National Cancer Institute concluded that there was an “emerging epidemic” of NHL and emphasized the need to investigate the factors responsible for the increasing incidence of this disease. Over the past two decades, numerous epidemiological studies have examined the risk factors for NHL, particularly for putative environmental and lifestyle risk factors, and international consortia have been established in order to investigate rare exposures and NHL subtype-specific associations. While few consistent risk factors for NHL aside from immunosuppression and certain infectious agents have emerged, suggestive associations with several lifestyle and environmental factors have been reported in epidemiologic studies. Further, increasing evidence has suggested that the effects of these and other exposures may be limited to or stronger for particular NHL subtypes. This paper examines the progress that has been made over the last twenty years in elucidating the etiology of NHL, with a primary emphasis on lifestyle factors and environmental exposures.