Interplay between TETs and microRNAs in the adult brain for memory formation.
Interplay between TETs and microRNAs in the adult brain for memory formation.
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成人大脑中TET和MicroRNA之间的相互作用以形成记忆。
DOI：
10.1038/s41598-018-19806-z
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发表时间：
2018-01-26
影响因子：
4.6
通讯作者：
Mansuy IM
中科院分区：
文献类型：
--
作者：
Kremer EA;Gaur N;Lee MA;Engmann O;Bohacek J;Mansuy IM
5-hydroxymethylation (5-hmC) is an epigenetic modification on DNA that results from the conversion of 5-methylcytosine by Ten-Eleven Translocation (TET) proteins. 5-hmC is widely present in the brain and is subjected to dynamic regulation during development and upon neuronal activity. It was recently shown to be involved in memory processes but currently, little is known about how it is controlled in the brain during memory formation. Here, we show that Tet3 is selectively up-regulated by activity in hippocampal neurons in vitro, and after formation of fear memory in the hippocampus. This is accompanied by a decrease in miR-29b expression that, through complementary sequences, regulates the level of Tet3 by preferential binding to its 3′UTR. We newly reveal that SAM68, a nuclear RNA-binding protein known to regulate splicing, acts upstream of miR-29 by modulating its biogenesis. Together, these findings identify novel players in the adult brain necessary for the regulation of 5-hmC during memory formation.
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影响因子：
16.2
作者：
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通讯作者：
Ressler, Kerry James
影响因子：
14.9
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DOI：
10.1073/pnas.0710263105
发表时间：
2008-04-29
影响因子：
11.1
作者：
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通讯作者：
De Strooper, Bart
影响因子：
16.8
作者：
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通讯作者：
Ding, Ye