Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1.
Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1.
复制标题
上颌窦腺鳞癌：对 S-1 完全缓解的病例。
DOI：
10.1017/s0022215109004538
复制
发表时间：
2009
影响因子：
1.7
通讯作者：
K. Ishikawa
中科院分区：
文献类型：
--
作者：
S. Suzuki;K. Hanata;H. Nanjo;K. Ishikawa
背景
BACKGROUND
Adenosquamous carcinoma is a very rare tumour which is characterised pathologically by the simultaneous presence of distinct areas of adenocarcinoma and squamous cell carcinoma. Generally, adenosquamous carcinoma has an aggressive clinical course and is associated with a poor prognosis. Most cases have been treated by surgery alone or combined with radiotherapy. Chemotherapy is rarely used in treating adenosquamous carcinoma, and it has been difficult to establish treatment guidelines due to the paucity of cases.
CASE
We report a case of adenosquamous carcinoma which arose in the maxillary sinus of a 77-year-old man. Despite surgical treatment and chemoradiotherapy to the primary site, he developed bilateral neck metastases after the surgery. The patient was treated with S-1, a novel oral fluoropyrimidine anticancer agent, with a complete (albeit finite) response.
CONCLUSION
This report presents the aggressive character of adenosquamous carcinoma and the possible role of S-1 in the treatment of this uncommon neoplasm.