Synthesis of Second- and Third-Generation Asp Oligopeptide Conjugated Dendrimers for Bone-Targeting Drug Delivery
Synthesis of Second- and Third-Generation Asp Oligopeptide Conjugated Dendrimers for Bone-Targeting Drug Delivery
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DOI：
10.1080/00397910902883660
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发表时间：
2009-10
影响因子：
2.1
通讯作者：
L. Ouyang;Junzhu Pan;Yu Zhang;Li Guo
中科院分区：
文献类型：
--
作者：
L. Ouyang;Junzhu Pan;Yu Zhang;Li Guo
Abstract The second- and third-generation multiple dendrimers based on naproxen in core and Asp(4–6) oligopeptides in periphery were synthesized in a convergent approach and well characterized by NMR and mass spectral (MS) techniques. These conjugates showed a high affinity to hydroxyapatite in vitro and provided an effective entry for the synthesis of a peptide dendrimer used for bone targeting.
