Deciphering ryanodine receptor array operation in cardiac myocytes.

Deciphering ryanodine receptor array operation in cardiac myocytes.
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破译兰尼碱受体阵列在心肌细胞中的作用

DOI:
10.1085/jgp.201010416
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发表时间:
2010-08
期刊:
The Journal of general physiology
影响因子:
--
通讯作者:
Cheng H
Cheng H
中科院分区:
其他
文献类型:
--
作者:
Xie W;Brochet DX;Wei S;Wang X;Cheng H

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通过不断改进的光学方法和其他创新技术,已经广泛表征了心肌细胞中运行的RYR阵列的元素钙信号。然而,就原位RYR门控而言,元素钙信号的确切性质仍然是一个谜。在这里,我们综合了从心脏RYR组织的单通道分辨率和比钙火花小得多的钙释放事件可视化的最新发展中收集到的见解。这种综合导致了一个概念框架的提议,承诺统一在火花学不同的观察。
Elemental calcium signals from RYR arrays operating in cardiac myocytes have been extensively characterized with ever-improving optical methods and other innovative techniques. However, the exact nature of elemental calcium signals in terms of RYR gating in situ remains an enigma. Here, we synthesize insights gleaned from recent developments in single-channel resolution of cardiac RYR organization and in visualization of calcium release events that are much smaller than calcium sparks. This synthesis leads to the proposal of a conceptual framework that promises to unify diverse observations in sparkology.
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发表时间: 1995-10-27
期刊: SCIENCE
影响因子: 56.9
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