EFFECT OF ACUTE AND CHRONIC METHAMPHETAMINE TREATMENT ON TYROSINE HYDROXYLASE ACTIVITY IN BRAIN AND ADRENAL MEDULLA
EFFECT OF ACUTE AND CHRONIC METHAMPHETAMINE TREATMENT ON TYROSINE HYDROXYLASE ACTIVITY IN BRAIN AND ADRENAL MEDULLA
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DOI：
10.1016/0014-2999(71)90008-2
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发表时间：
1971-01-01
影响因子：
5
通讯作者：
MCGEER, EG
中科院分区：
文献类型：
--
作者：
FIBIGER, HC;MCGEER, EG
研究甲基苯丙胺对大鼠脑和肾上腺髓质酪氨酸羟化酶的影响。甲基苯丙胺（10毫克/公斤）的长期管理导致这种酶在肾上腺髓质的活性增加，在脑干或下丘脑没有影响，抑制纹状体。在相同的条件下，较低剂量的甲基苯丙胺（5毫克/公斤）没有显着影响酪氨酸羟化酶的活性，在任何这些结构。急性甲基苯丙胺治疗在任何剂量未能修改酪氨酸水解酶活性。不同的影响排除了甲基苯丙胺对该系统的直接药理作用。肾上腺髓质中酪氨酸羟化酶活性的增加被解释为对高剂量甲基苯丙胺的非特异性应激反应。结果支持先前假设的脑中存在神经元间反馈机制，该机制可以调节多巴胺合成（Carlsson和Lindqvist，1963），并且这可能至少部分通过对酪氨酸羟化酶活性的影响发挥作用。
The effect of methamphetamine on tyrosine hydroxylase in brain and adrenal medulla of rats was investigated. Chronic administration of methamphetamine (10 mg/kg) resulted in increased activity of this enzyme in the adrenal medulla, no effect in the brain stem or hypothalamus, and inhibition in the corpus striatum. Under the same conditions, a lower dosage of methamphetamine (5 mg/kg) did not significantly influence tyrosine hydroxylase activity in any of these structures. Acute methamphetamine treatment at either dosage failed to modify tyrosine hydrocylase activity. The diverse effects preclude a direct pharmacological action of methamphetamine on this system. The increased tyrosine hydroxylase activity in the adrenal medulla was interpreted as a non-specific stress reaction to high doses of methamphetamine. The results support the presence of a previously postulated interneuronal feedback mechanism in brain which can regulate dopamine synthesis (Carlsson and Lindqvist, 1963) and this may function at least in part through an effect on tyrosine hydroxylase activity.