How Dietary Patterns are Related to Inflammaging and Mortality in Community-Dwelling Older Chinese Adults in Hong Kong A Prospective Analysis
How Dietary Patterns are Related to Inflammaging and Mortality in Community-Dwelling Older Chinese Adults in Hong Kong A Prospective Analysis
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DOI：
10.1007/s12603-018-1143-0
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发表时间：
2019-02-01
影响因子：
5.8
通讯作者：
Woo, J.
中科院分区：
文献类型：
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作者：
Chan, Ruth S. M.;Yu, B. W. M.;Woo, J.
研究饮食模式和炎症与死亡率之间的关系是有限的。目的：考虑人口统计学、生活方式因素和血清炎症标志物，研究各种饮食模式对全因和心血管疾病（CVD）死亡率的影响。方法我们使用来自香港社区居住的中国老年人队列（1406名男性，1396名女性）的数据进行多变量Cox回归分析。基线采访者管理的问卷包括饮食摄入量估计和饮食模式生成，从食物频率问卷，人口和生活方式因素，认知功能和抑郁症状。测定血清高敏c反应蛋白（hsCRP）和25-羟基维生素D （25OHD）。14年随访的全因死亡率和心血管疾病死亡率数据从官方数据库中检索。结果男性hsCRP水平越高，饮食质量指数-国际（DQI-I）评分、地中海- dash干预神经退行性延迟饮食（MIND）评分、冲绳饮食评分、蔬菜-水果模式评分和零食-饮料-牛奶模式评分越低。较高的血清25OHD水平与较高的地中海饮食评分（MDS）相关，但与较低的零食-饮料-牛奶模式评分相关。在调整所有协变量后，饮食模式评分与全因或心血管疾病死亡率均无相关性。在女性中，hsCRP水平和血清25OHD水平与任何饮食模式无关。在多因素调整模型中，较高的DQI-I评分（HR=0.77 （95% CI: 0.59, 0.99）最高和最低的分位数，p-trend=0.038）和冲绳饮食评分（HR=0.78 （95% CI: 0.61, 1.00）最高和最低的分位数，p-trend=0.046）与较低的全因死亡风险相关，而较高的MIND评分（HR=0.63 （95% CI: 0.36, 1.09）最高和最低的分位数，p-trend=0.045）与较低的心血管疾病道德风险相关。结论较高的DQI-I评分和冲绳饮食评分与较低的全因死亡风险相关，较高的MIND饮食依从性与降低社区居住中国老年妇女CVD死亡风险相关。
IntroductionStudies examining dietary patterns and inflammageing in relation to mortality are limited.ObjectiveWe examined the influence of various dietary patterns on all-cause and cardiovascular disease (CVD) mortality, taking into account demographics, lifestyle factors, and serum inflammatory markers.MethodsWe conducted multivariate Cox regression analyses using data from a cohort of communitydwelling older Chinese adults (1,406 men, 1,396 women) in Hong Kong. Baseline interviewer administered questionnaires covered dietary intake estimation and dietary pattern generation from the food frequency questionnaire, demographic and lifestyle factors, cognitive function and depressive symptoms. Serum high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25OHD) were measured. All-cause and CVD mortality data at 14-year follow up were retrieved from an official database.ResultsIn men, higher hsCRP level was associated with lower Diet Quality Index-International (DQI-I) score, Mediterranean-DASH Intervention for Neurodegenerative Delay Diet (MIND) score, Okinawan diet score, vegetables-fruits pattern score and snacks-drinks-milk pattern score. Higher serum 25OHD level was associated with higher Mediterranean Diet Score (MDS) but lower snacks-drinks-milk pattern score. None of the dietary pattern scores was associated with all-cause or CVD mortality after adjusting for all covariates. In women, hsCRP level and serum 25OHD level were not associated with any dietary patterns. Higher DQI-I score (HR=0.77 (95% CIs: 0.59, 0.99) highest vs. lowest tertile, p-trend=0.038) and Okinawan diet score (HR=0.78 (95% CIs: 0.61, 1.00) highest vs lowest tertile, p-trend=0.046) was associated with a lower risk of all-cause mortality, whereas higher MIND score (HR=0.63 (95% CI: 0.36, 1.09) highest vs. lowest tertile, p-trend=0.045) was associated with a reduced risk of CVD morality in the multivariate adjusted model.ConclusionHigher DQI-I score and Okinawan diet score were associated with a lower risk of all-cause mortality, and higher adherence to the MIND diet was related to a reduced risk of CVD mortality in community-dwelling Chinese older women.