One-Hour Post load Plasma Glucose Levels Are Associated with Kidney Dysfunction
One-Hour Post load Plasma Glucose Levels Are Associated with Kidney Dysfunction
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DOI：
10.2215/cjn.03240410
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发表时间：
2010-11-01
影响因子：
9.8
通讯作者：
Sesti, Giorgio
中科院分区：
文献类型：
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作者：
Succurro, Elena;Arturi, Franco;Sesti, Giorgio
背景和目的：口服葡萄糖耐量试验（OGTT）中1小时负荷后血浆葡萄糖（1hPG）的临界值为155 mg/dl，可以识别出2型糖尿病和血管粥样硬化的高危患者。我们的目的是检查1hPG >= 155 mg/dl的个体是否也有慢性肾脏疾病（CKD）的风险增加。设计、设置、参与者和测量：通过慢性肾病流行病学协作方程对1075名无糖尿病的白人进行动脉粥样硬化危险因素、OGTT和估计GFR分析。结果：与葡萄糖浓度为0、30、2小时时相比，1hPG时的受试者工作特征曲线下面积最大（0.700）。与1hPG = 155 mg/dl的个体相比，1hPG = 155 mg/dl的个体患CKD的风险增加，患CKD的风险高于1hPG的个体
Background and objectives: A cutoff of 155 mg/dl for 1-hour postload plasma glucose (1hPG) during the oral glucose tolerance test (OGTT) is able to identify patients who are at high risk for type 2 diabetes and vascular atherosclerosis. We aimed to examine whether individuals with 1hPG >= 155 mg/dl are also at increased risk for chronic kidney disease (CKD).Design, setting, participants, & measurements: Atherosclerosis risk factors, OGTT, and estimated GFR by Chronic Kidney Disease Epidemiology Collaboration equation were analyzed in 1075 white individuals without diabetes.Results: The area under the receiver operating characteristic curve for 1hPG was the highest (0.700) compared with the areas under the receiver operating characteristic curve of 0, 30-minute, and 2-hour glucose concentrations. Individuals with 1hPG = 155 mg/dl showed an increased risk for CKD compared with individuals with 1hPG = 155 mg/dl showed a higher risk for CKD compared with individuals with 1hPG