MRI hyperintensities and depressive symptoms in a community sample of individuals 60-64 years old
MRI hyperintensities and depressive symptoms in a community sample of individuals 60-64 years old
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DOI：
10.1176/appi.ajp.162.4.699
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发表时间：
2005-04-01
影响因子：
17.7
通讯作者：
Sachdev, P
中科院分区：
文献类型：
--
作者：
Jorm, AF;Anstey, KJ;Sachdev, P
目的：以往的研究发现磁共振成像（MRI）信号高强度与老年人抑郁症有关。本研究调查了一个较年轻的社区样本（60 - 64岁）抑郁受试者和对照组的关联，以寻找潜在的中介和混杂变量。方法：从一个较大的社区调查中抽取475名60 - 64岁的人进行脑MRI扫描。使用自动程序定量白质高信号，使用半定量视觉分级定量基底节区高信号。该研究还评估了抑郁症状和抗抑郁药物的使用情况。评估的潜在中介或混杂变量包括身体残疾、高血压、中风、糖尿病、头部损伤、皮质醇、促甲状腺激素、认知功能、吸烟和饮酒。结果：抑郁症状与全脑白质高信号有关，而与基底神经节高信号无关。然而，当对身体残疾和吸烟进行统计调整时，这种关联就消失了。结论：在一个社区样本中，抑郁症状与中年白质高信号有关。身体残疾似乎在这一关联中起着重要作用。
Objective: Previous studies have found associations of magnetic resonance imaging (MRI) signal hyperintensities with depression in the elderly. The present study investigates the association in a younger community sample ( age 60 - 64 years) of depressed subjects and comparison groups for potential mediating and confounding variables.Method: A subsample of 475 persons 60 - 64 years of age from a larger community survey underwent brain MRI scans. White matter hyperintensities were quantified by using an automated procedure, and basal ganglia hyperintensities were quantified by using semiquantitative visual ratings. The study also assessed depressive symptoms and use of antidepressant medication. Potential mediating or confounding variables assessed included physical disability, hypertension, stroke, diabetes, head injury, cortisol, thyroid-stimulating hormone, cognitive functioning, smoking, and alcohol use.Results: Depressive symptoms were found to be related to total brain white matter hyperintensities but not to basal ganglia hyperintensities. However, associations disappeared when statistical adjustment was made for physical disability and smoking.Conclusions: Depressive symptoms are related to white matter hyperintensities in mid-adult life in a community sample. Physical disability appears to play an important role in this association.