High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease.
High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease.
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DOI：
10.3389/fimmu.2016.00336
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发表时间：
2016
影响因子：
7.3
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Hou D;Chen C;Seely EJ;Chen S;Song Y
适应性免疫应答的选择性基于T和B细胞抗原特异性受体的巨大多样性。免疫库，即在任何给定时间循环系统中具有功能多样性的T和B细胞的集合，是动态的，反映了免疫选择性的本质。本文从传统技术和高通量测序技术两个方面综述了近年来感染性疾病免疫谱研究的进展。HTS技术能够以前所未有的效率和规模确定淋巴细胞受体的互补区域。方法学的这一进展增强了对病原体挑战期间免疫学变化的理解，也为进一步开发新的诊断标记物、免疫疗法和疫苗提供了基础。
The selectivity of the adaptive immune response is based on the enormous diversity of T and B cell antigen-specific receptors. The immune repertoire, the collection of T and B cells with functional diversity in the circulatory system at any given time, is dynamic and reflects the essence of immune selectivity. In this article, we review the recent advances in immune repertoire study of infectious diseases, which were achieved by traditional techniques and high-throughput sequencing (HTS) techniques. HTS techniques enable the determination of complementary regions of lymphocyte receptors with unprecedented efficiency and scale. This progress in methodology enhances the understanding of immunologic changes during pathogen challenge and also provides a basis for further development of novel diagnostic markers, immunotherapies, and vaccines.
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影响因子：
64.5
作者：
Birnbaum ME;Mendoza JL;Sethi DK;Dong S;Glanville J;Dobbins J;Ozkan E;Davis MM;Wucherpfennig KW;Garcia KC
通讯作者：
Garcia KC
影响因子：
8.8
作者：
Dziubianau, M.;Hecht, J.;Babel, N.
通讯作者：
Babel, N.
影响因子：
5.4
作者：
Costa, Ana I.;Koning, Dan;van Baarle, Debbie
通讯作者：
van Baarle, Debbie
DOI：
10.1073/pnas.1417683112
发表时间：
2015-02-24
影响因子：
11.1
作者：
Gadala-Maria, Daniel;Yaari, Gur;Kleinstein, Steven H.
通讯作者：
Kleinstein, Steven H.
影响因子：
4.4
作者：
Balamurugan, Arumugam;Ng, Hwee L.;Yang, Otto O.
通讯作者：
Yang, Otto O.