Composite block copolymer stabilized nanoparticles: Simultaneous encapsulation of organic actives and inorganic nanostructures
Composite block copolymer stabilized nanoparticles: Simultaneous encapsulation of organic actives and inorganic nanostructures
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DOI：
10.1021/la702902b
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发表时间：
2008-01-01
期刊：
影响因子：
3.9
通讯作者：
Prud'homme, Robert K.
中科院分区：
文献类型：
--
作者：
Gindy, Marian E.;Panagiotopoulos, Athanassios Z.;Prud'homme, Robert K.
我们描述了杂化嵌段共聚纳米颗粒(NPs)的制备和表征，用于药物和显像剂的多模式载体。采用闪蒸纳米沉淀法在多入口涡流混合器中制备了稳定、水溶性、生物相容的聚乙二醇聚己内酯嵌段聚己内酯纳米粒子，同时共包裹了疏水性有机活性物质(β-胡萝卜素)和无机成像纳米结构(Au)。这些复合纳米粒子(CNP)的尺寸在75 nm到275 nm之间可调，粒度分布窄，包封率高，特定的组分组成，以及长期稳定性。该过程是可调的和灵活的，因为它依赖于混合和聚合时间尺度的控制。预计该技术可以应用于各种疏水活性化合物、荧光染料和无机纳米结构，产生用于联合治疗和多模式成像应用的CNP。
We describe the preparation and characterization of hybrid block copolymer nanoparticles (NPs) for use as multimodal carriers for drugs and imaging agents. Stable, water-soluble, biocompatible poly(ethylene glycol)-block-poly(epsilon-caprolactone) NPs simultaneously co-encapsulating hydrophobic organic actives (beta-carotene) and inorganic imaging nanostructures (Au) are prepared using the flash nanoprecipitation process in a multi-inlet vortex mixer. These composite nanoparticles (CNPs) are produced with tunable sizes between 75 nm and 275 nm, narrow particle size distributions, high encapsulation efficiencies, specified component compositions, and long-term stability. The process is tunable and flexible because it relies on the control of mixing and aggregation timescales. It is anticipated that the technique can be applied to a variety of hydrophobic active compounds, fluorescent dyes, and inorganic nanostructures, yielding CNPs for combined therapy and multimodal imaging applications.