Schwann cell-derived desert hedgehog controls the development of peripheral nerve sheaths
Schwann cell-derived desert hedgehog controls the development of peripheral nerve sheaths
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DOI：
10.1016/s0896-6273(01)80030-1
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发表时间：
1999-08-01
期刊：
影响因子：
16.2
通讯作者：
Mirsky, R
中科院分区：
文献类型：
--
作者：
Parmantier, E;Lynn, B;Mirsky, R
我们发现，雪旺细胞衍生的沙漠刺猬（Dhh）是周围神经结缔组织鞘形成的信号，Dhh及其受体补丁（ptc）的mrna分别在雪旺细胞和神经周围间质中表达。在dhh（-/-）小鼠中，神经外膜胶原蛋白减少，神经周围膜薄且无组织，基底膜呈斑片状，连接蛋白43不能表达。神经周围紧密连接异常，允许蛋白质和中性粒细胞通过。在神经成纤维细胞中，Dhh上调ptc和刺猬相互作用蛋白（hip）。这些实验揭示了神经胶质细胞和间充质结缔组织之间的一种新的发育信号通路，并证明了其在周围神经中的分子特性。他们还表明，雪旺细胞衍生的信号可以作为神经发育的重要调节因子。
We show that Schwann cell-derived Desert hedgehog (Dhh) signals the formation of the connective tissue sheath around peripheral nerves, mRNAs for dhh and its receptor patched (ptc) are expressed in Schwann cells and perineural mesenchyme, respectively. In dhh(-/-) mice, epineurial collagen is reduced, while the perineurium is thin and disorganized, has patchy basal lamina, and fails to express connexin 43. Perineurial tight junctions are abnormal and allow the passage of proteins and neutrophils. In nerve fibroblasts, Dhh upregulates ptc and hedgehog-interacting protein (hip). These experiments reveal a novel developmental signaling pathway between glia and mesenchymal connective tissue and demonstrate its molecular identity in peripheral nerve. They also show that Schwann cell-derived signals can act as important regulators of nerve development.