Anesthetic protocol:: propofol use in Rhesus macaques (Macaca mulatta) during magnetic resonance imaging with stereotactic head frame application
Anesthetic protocol:: propofol use in Rhesus macaques (Macaca mulatta) during magnetic resonance imaging with stereotactic head frame application
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DOI：
10.1016/s1385-299x(00)00051-9
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发表时间：
2001-06-01
期刊：
影响因子：
--
通讯作者：
Subramanian, T
中科院分区：
文献类型：
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作者：
Fowler, KA;Huerkamp, MJ;Subramanian, T
磁共振成像（MRI）引导对于用于实验研究的动物立体定向颅内手术的准确靶向通常是必要的。磁共振成像设备产生的磁场。在有限空间中使用立体定向头架的逻辑和在成像期间限制对象移动的需要产生了独特的挑战。我们在这项研究中证明了静脉注射异丙酚麻醉成年恒河猴获得高分辨率3D MR图像，然后立即转换为吸入麻醉和立体定向颅内手术与头架原位的有用性。“在立体定向靶向达到高度精确的情况下，发病率最低。(C)2001 Elsevier Science B.V.保留所有权利。
Magnetic resonance image (MRI) guidance is often necessary for accurate targeting for stereotactic intracranial surgery in animals used for experimental research studies. The magnetic field created by the MR imaging equipment. logistics of the use of stereotactic head frame in confined space and the need to limit movement of the subject during the imaging creates unique challenges. We demonstrate in this study the usefulness of intravenous propofol to anesthetize adult Rhesus monkeys to obtain high resolution 3D MR images immediately followed by conversion to inhalation anesthesia and stereotactic intracranial surgery with the head frame 'in situ.' There was minimal morbidity with achieving a high degree of precision for the stereotactic targeting. (C) 2001 Elsevier Science B.V. All rights reserved.