Self-reported sleep disturbance as a prodromal symptom in recurrent depression
Self-reported sleep disturbance as a prodromal symptom in recurrent depression
复制标题
DOI：
10.1016/s0165-0327(96)01411-5
复制
发表时间：
1997-02-01
影响因子：
6.6
通讯作者：
Kupfer, DJ
中科院分区：
文献类型：
--
作者：
Perlis, ML;Giles, DE;Kupfer, DJ
1.没有睡眠相关失眠主诉的介绍（Breslau等人，1996年）的报告。睡眠障碍，当相比之下，睡眠障碍的投诉一直其他抑郁症状，约占60%，是一个明确的特征，情绪障碍。这是预测的方差。虽然从流行病学研究中可以清楚地看出，睡眠障碍只是抑郁症的一种症状，但实际上可能发生的是，睡眠障碍可能代表了抑郁症发展的全部因素的发展之前的脆弱性，并预示着抑郁症的发展，但它不是临床综合征。最近，三项主要的研究表明睡眠障碍是否与人口学研究有关，这些研究提供了提示临床过程的数据。什么是不清楚从以前的失眠是抑郁症的危险因素。在这些研究中，发现（1）睡眠障碍是否成为第一位，在急性发作之前立即恶化的持续性失眠症患者发生抑郁发作的可能性是三倍，和/或（2）在一年间隔内缓解抑郁症是否比急性发作的患者在没有持续性失眠的情况下提前或提前（福特和卡默罗，改善睡眠。在本研究中，我们评估了1989年）。在第二，四个抑郁症状的纵向过程中缓解的患者，以在一年的过程中测量间，以确定是否失眠投诉之前瓦尔，发现与发展的充分抑郁的临床新的抑郁发作。四种症状综合征。睡眠受到干扰，内疚感增加，注意力和性欲下降（Dryman和Eaton，1991）。然而，睡眠障碍仅预测了新的2。妇女的主题和方法。在第三项研究中，对于具有终生病史的受试者，本研究的数据是从关于Interperson治疗两周或更长时间的失眠的疗效比受试者治疗（IPT）和社会zietgebers在维持缓解中的重要性的更大研究中获得的四倍大的数据（Buysse等人，*通讯作者。1992年）。参加IPT的所有受试者，
1. Introduction without sleep-related insomnia complaints (Breslau et al., 1996). Sleep disturbance, when compared to The complaint of sleep disturbance has always other depressive symptoms, accounted for about 60% been a defining feature of mood disorders. This of the predicted variance. complaint, which has traditionally been considered While it is clear from the epidemiologic studies only a symptom of depression, may actually occur that sleep disturbance may represent a vulnerability prior to, and presage, the development of the full factor for the development of depression, it is not clinical syndrome. Recently, three major epi- clear whether sleep disturbance varies in relation to demiologic studies have provided data that suggest clinical course. What is not clear from the previous that insomnia is a risk factor for depression. In the studies is (1) whether sleep disturbance becomes first, patients with persistent insomnia complaints worse immediately prior to the onset of an acute were found to be three times more likely to develop depressive episode and/or (2) whether remission depression within a one year interval than patients from acute episodes is preceded or paralleled by without persistent insomnia (Ford and Kamerow, improved sleep. In the present study, we evaluated 1989). In the second, four depressive symptoms the longitudinal course of remitted patients in order were, over the course of a year measurement inter- to determine whether insomnia complaints precede val, found to be associated with the development of the development of the full depressive clinical new episodes of depression. The four symptoms syndrome. were disturbed sleep, increased guilt and decreased concentration and libido (Dryman and Eaton, 1991). Sleep disturbance, however, only predicted new 2. Subjects and methods episodes in women. In the third, gender-adjusted relative risk for new onset of major depression was Data for the present study were obtained from a four times greater for subjects with a lifetime history larger study on the treatment efficacy of Interpersonof two weeks or more of insomnia than subjects al Therapy (IPT) and the importance of social zietgebers in maintaining remission (Buysse et al.,* Corresponding author. 1992). All subjects participating in the IPT and