Neuropsychological evidence for the crucial role of the right arcuate fasciculus in the face-based mentalizing network: A disconnection analysis
Neuropsychological evidence for the crucial role of the right arcuate fasciculus in the face-based mentalizing network: A disconnection analysis
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DOI：
10.1016/j.neuropsychologia.2018.01.024
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发表时间：
2018-07-01
期刊：
影响因子：
2.6
通讯作者：
Herbet, Guillaume
中科院分区：
文献类型：
--
作者：
Nakajima, Riho;Yordanova, Yordanka N.;Herbet, Guillaume
最近来自轴突刺激映射研究的证据表明，右半球中至少有两个白色物质连接可能涉及基于面部的心理化，即从人脸推断复杂认知和情感状态的能力：下额枕（IFOF）和上级纵向/弓形（SLF/AF）束。然而，到目前为止，只有少数神经心理学研究集中在白色物质束一般促进心理化，特别是基于面部的心理化。因此，本研究的主要目标是通过将体素和tractwise病变症状分析应用于从一个大型且同质的神经系统参与者组获得的一组行为数据来确认上述结果。更准确地说，122例弥漫性低级别胶质瘤手术患者术后进行了评估，充分验证的“阅读眼睛的思想”（RME）测试。对于每例患者，切除腔和残余肿瘤浸润分别映射在各自的术后结构MRI上。行为数据，以前控制的社会人口因素，然后提交到一个标准的基于体素和一个不太保守的，区域的利益（ROI）为基础的，病变赤字分析。结果总是相同的：没有解剖功能的关系，这些调查被查明，从而使不可能的大脑皮层拓扑定位的心智缺陷。在第二次，两种tractwise病变症状分析的基础上受损的体积和断开概率的白色物质束，进行。所有结果均采用Bonferroni校正进行校正。汇聚和强有力的证据表明，切除相关的断开右侧AF是特别有害的脸为基础的心理化。更有趣的是，我们确定了某些腹侧束的参与，特别是IFOF和钩束（UF）。作为一个整体，报告的结果证实了正确的AF在心智化能力的关键作用。从更临床的角度来看，他们强调了在清醒手术期间进行这种连接的术中地图的必要性，以避免长期的社会认知障碍。
Recent evidence from axonal stimulation mapping studies suggests that at least two white matter connectivities in the right hemisphere may be involved in face-based mentalizing, i.e. the ability to infer complex cognitive and affective states from human faces: the inferior fronto-occipital (IFOF) and the superior longitudinal/arcuate (SLF/AF) fasciculi. However, to date, only a handful of neuropsychological studies have focused on the white matter tracts subserving mentalizing in general, and face-based mentalizing in particular. Therefore, the main goal of this study was to confirm the abovementioned results by applying voxelwise and tractwise lesion symptom analyses to a set of behavioral data obtained from a large and homogeneous group of neurological participants. More precisely, 122 patients operated on for diffuse low-grade glioma were assessed postoperatively with the well-validated "Reading the Mind in the Eyes" (RME) test. For each patient, the resection cavity and the residual tumor infiltration were mapped separately on the respective postoperative structural MRI. Behavioral data, previously controlled for sociodemographic factors, were then submitted to a standard voxel-based and to a less conservative, region-of-interest (ROI)-based, lesion-deficit analyses. Results were invariably the same: no anatomo-functional relationships were pinpointed by these investigations, making thus impossible the cortical topological localization of mentalizing deficits. In a second time, two kinds of tractwise lesion-symptom analyses based on the damaged volume and the disconnection probabilities of the white matter tracts, were performed. All results were corrected with the Bonferroni correction. Converging and strong evidence was found that resection-related disconnection of the right AF is especially deleterious for face-based mentalizing. More anecdotally, we identified the involvement of certain ventral tracts, especially the IFOF and the uncinate fasciculus (UF). Taken as a whole, the reported findings confirm the critical role of the right AF in mentalizing abilities. From a more clinical standpoint, they highlight the necessity to perform an intraoperative map of this connectivity during awake surgery in order to avoid long-lasting social cognition disorders.