Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors.
Xi-Xian-Tong-Shuan capsule alleviates vascular cognitive impairment in chronic cerebral hypoperfusion rats by promoting white matter repair, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors.
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西咸通栓胶囊通过促进白质修复、减少神经元丢失以及抑制促炎因子表达，改善慢性脑灌注不足大鼠的血管性认知障碍。
DOI：
10.1016/j.biopha.2021.112453
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Feng Yan;Yue Tian;Yuyou Huang;Qi Wang;Ping Liu;Ningqun Wang;Fangfang Zhao;Liyuan Zhong
中科院分区：
文献类型：
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作者：
Feng Yan;Yue Tian;Yuyou Huang;Qi Wang;Ping Liu;Ningqun Wang;Fangfang Zhao;Liyuan Zhong
背景慢性脑灌注不足（CCH）所致的血管性认知功能障碍的病例数逐年增加，但目前尚无有效的治疗方法。目前，息仙通栓胶囊主要用于急性脑缺血患者;但是，在此情况下，目的探讨希仙通栓胶囊对慢性脑血管病（CCH）所致认知功能障碍的保护作用机制。方法采用双侧颈总动脉结扎法建立无特定病原体（SPF）级SD大鼠CCH模型。BCCAO）。BCCAO术后给予息纤通栓胶囊灌胃42天。然后，我们评估了认知功能、促炎因子表达水平和凝血功能的变化，以及是否存在白色病变和神经元丢失。结果BCCAO手术后大鼠表现出明显的认知功能障碍，沿着白色病变，神经元丢失，炎症因子水平升高，经希仙通栓胶囊干预后，上述指标均明显逆转。舒安胶囊可通过防止白色物质损伤、减少神经元丢失、抑制促炎因子表达等途径改善CCH大鼠血管性认知功能障碍。本研究为希仙通栓胶囊治疗慢性脑缺血的临床研究提供了新的参考。
BackgroundWhile the number of cases of vascular cognitive impairment caused by chronic cerebral hypoperfusion (CCH) has been increasing every year, there are currently no clinically effective treatment methods. At present, Xi-Xian-Tong-Shuan capsule is predominantly used in patients with acute cerebral ischemia; however, its protective effect on CCH has rarely been reported.ObjectiveTo explore the underlying mechanisms by which Xi-Xian-Tong-Shuan capsule alleviates cognitive impairment caused by CCH.MethodsA model of CCH was established in specific-pathogen-free (SPF)-grade male Sprague-Dawley (SD) rats using bilateral common carotid artery occlusion (BCCAO). Xi-Xian-Tong-Shuan capsules were intragastrically administered for 42 days after the BCCAO surgery. We then assessed for changes in cognitive function, expression levels of pro-inflammatory factors, and coagulation function as well as for the presence of white matter lesions and neuronal loss. One-way ANOVA and Tukey's test were used to analyze the experimental data.ResultsThe rats showed significant cognitive dysfunction after the BCCAO surgery along with white matter lesions, a loss of neurons, and elevated levels of inflammatory factors, all of which were significantly reversed after intervention with Xi-Xian-Tong-Shuan capsules.ConclusionXi-Xian-Tong-Shuan capsules can ameliorate vascular cognitive impairment in CCH rats by preventing damage of white matter, reducing neuronal loss, and inhibiting the expression of pro-inflammatory factors. Our study provides a new reference for the clinical treatment of chronic cerebral ischemia with Xi-Xian-Tong-Shuan capsules.