Free radical-mediated activation of hydrazine derivatives.
Free radical-mediated activation of hydrazine derivatives.
复制标题
自由基介导的肼衍生物的激活。
DOI：
10.1289/ehp.8564179
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发表时间：
1985-12
影响因子：
10.4
通讯作者：
Sinha BK
中科院分区：
文献类型：
--
作者：
Kalyanaraman B;Sinha BK
已知肼在几种体外酶系统中经历氧化活化。自由基或碳正离子已被提出作为这种活化过程中的活性中间体。肼引起的毒性作用也与自由基介导的活化有关。本文综述了用直接ESR和ESR-自旋捕集法鉴定肼类有机自由基的研究进展。
Hydrazines are known to undergo oxidative activation in several enzymatic systems in vitro. Free radicals or carbonium ions have been proposed as active intermediates during such activation. The toxic effects elicited by hydrazines have also been linked to free radical-mediated activation. In this report, we have reviewed the identification of organic free radicals from hydrazines by direct ESR and ESR-spin trapping.