Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.
Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.
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DOI：
10.1152/ajpheart.01036.2007
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发表时间：
2008-02
期刊：
影响因子：
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通讯作者：
C. Zeng;I. Armando;Yingjin Luo;G. Eisner;R. Felder;P. Jose
中科院分区：
文献类型：
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作者：
C. Zeng;I. Armando;Yingjin Luo;G. Eisner;R. Felder;P. Jose
多巴胺通过调节上皮钠转运和通过与血管活性激素/体液因子（如醛固酮、血管紧张素、儿茶酚胺、内皮素、催产素、催乳素原-阿黑皮素、活性氧、肾素和加压素）相互作用在高血压的发病机制中起重要作用。多巴胺受体根据其结构和药理学分为D（1）-样（D（1）和D（5））和D（2）-样（D（2）、D（3）和D（4））亚型。近年来，已经产生了五种多巴胺受体亚型中一种或多种缺乏的小鼠，从而更好地理解了每种多巴胺受体亚型的生理作用。本文综述了不同多巴胺受体突变小鼠对多巴胺受体亚型及其与其他G蛋白偶联受体在血压调节中的作用的研究结果。
Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D(1)-like (D(1) and D(5)) and D(2)-like (D(2), D(3), and D(4)) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understanding of the physiological role of each of the dopamine receptor subtypes. This review summarizes the results from studies of various dopamine receptor mutant mice on the role of individual dopamine receptor subtypes and their interactions with other G protein-coupled receptors in the regulation of blood pressure.