Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study
Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study
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DOI：
10.1002/ijc.33016
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发表时间：
2020-06-02
影响因子：
6.4
通讯作者：
Jones, Rena R.
中科院分区：
文献类型：
--
作者：
Xiao, Qian;James, Peter;Jones, Rena R.
昼夜节律紊乱可能在乳腺癌发生中起作用。以前的研究报告了夜间户外光线（LAN）与乳腺癌风险之间的关系，但他们的发现是混合的。还需要根据不同的个人和环境特征检查LAN和乳腺癌的发病率，以确定与LAN暴露相关的风险更大的亚群。我们研究了186981名绝经后妇女（包括NIH-AARP饮食与健康研究中的12318例绝经后乳腺癌病例）在基线（1996年）时根据卫星图像估计的住宅室外LAN与绝经后乳腺癌发病率的关系，随访时间与16年相似。我们使用考克斯比例风险模型来估计LAN五分位数与绝经后乳腺癌风险之间关系的风险比（HR）和双侧95%置信区间（CI），总体和激素受体状态和癌症分期。我们发现，与基线LAN最低五分位数的妇女相比，LAN最高五分位数的妇女绝经后乳腺癌风险增加10%（HR（95% CI），1.10（1.02，1.18），P趋势，0.002）。雌激素受体（ER）阳性乳腺癌（1.12 [1.02，1.24]，0.007）的相关性似乎比ER阴性乳腺癌（1.07 [0.85，1.34]，0.66）更强。我们的研究结果还表明，LAN和乳腺癌风险之间的关系可能因个体特征而异，如吸烟，饮酒，睡眠时间和BMI以及社区环境。总之，我们的研究表明，较高的户外局域网暴露可能是绝经后乳腺癌的危险因素。
Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in relation to postmenopausal breast cancer incidence over similar to 16 years of follow-up in 186 981 postmenopausal women including 12 318 incident postmenopausal breast cancer cases in the NIH-AARP Diet and Health Study. We used Cox proportional hazards models to estimate hazard ratios (HR) and two-sided 95% confidence intervals (CI) of the relationship between quintiles of LAN and postmenopausal breast cancer risk, overall and by hormone receptor status and cancer stage. We found that when compared to women in the lowest quintile of baseline LAN, those in the highest quintile had a 10% increase in postmenopausal breast cancer risk (HR (95% CI), 1.10 (1.02, 1.18), P-trend, .002). The association appeared to be stronger for estrogen receptor (ER) positive breast cancer (1.12 [1.02, 1.24], .007) than for ER-negative cancer (1.07 [0.85, 1.34], .66). Our findings also suggested that the relationship between LAN and breast cancer risk may differ by individual characteristics, such as smoking, alcohol drinking, sleep duration and BMI, and neighborhood environment. In conclusion, our study suggests that higher outdoor LAN exposure may be a risk factor for postmenopausal breast cancer.