Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice.
Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice.
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DOI：
10.1186/1297-9686-37-3-151
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发表时间：
2005-03
期刊：
影响因子：
--
通讯作者：
Pomp D
中科院分区：
文献类型：
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作者：
Leamy LJ;Elo K;Nielsen MK;Dale Van Vleck L;Pomp D
我们估计遗传力和遗传相关性的一套15个字符在5个功能组中的先进的intercross人口超过2000小鼠来自高，低热量损失选择的近交系杂交。三个体重的遗传力平均为0.56，两个能量平衡性状的遗传力平均为0.23，三个骨骼性状的遗传力平均为0.48，四个肥胖指标的遗传力平均为0.35，三个器官重量的遗传力平均为0.27，所有这些遗传力的大小与以前的研究中得出的估计值基本一致。遗传相关性从-0.65到+0.98不等，并且在这些功能组内高于组间。这些相关性通常符合先验预期，能量消耗和消耗的符号为正（+0.24），能量消耗和肥胖的符号为负（-0.17）。肥胖与3、6、12周龄体重的遗传相关（-0.29、-0.22、-0.26）均为负相关，但无统计学意义。体重和肥胖的独立性表明，这种先进的杂交人口是理想的全面发现的基因控制调节哺乳动物肥胖，是不同于那些体重。
We estimated heritabilities and genetic correlations for a suite of 15 characters in five functional groups in an advanced intercross population of over 2000 mice derived from a cross of inbred lines selected for high and low heat loss. Heritabilities averaged 0.56 for three body weights, 0.23 for two energy balance characters, 0.48 for three bone characters, 0.35 for four measures of adiposity, and 0.27 for three organ weights, all of which were generally consistent in magnitude with estimates derived in previous studies. Genetic correlations varied from -0.65 to +0.98, and were higher within these functional groups than between groups. These correlations generally conformed to a priori expectations, being positive in sign for energy expenditure and consumption (+0.24) and negative in sign for energy expenditure and adiposity (-0.17). The genetic correlations of adiposity with body weight at 3, 6, and 12 weeks of age (-0.29, -0.22, -0.26) all were negative in sign but not statistically significant. The independence of body weight and adiposity suggests that this advanced intercross population is ideal for a comprehensive discovery of genes controlling regulation of mammalian adiposity that are distinct from those for body weight.