Regulation and consequences of cellular changes in the prothoracic glands of Manduca sexta during the last larval instar: a review.
Regulation and consequences of cellular changes in the prothoracic glands of Manduca sexta during the last larval instar: a review.
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最后幼虫龄期间天蛾前胸腺细胞变化的调节和后果：综述。
DOI：
10.1002/arch.940300214
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Smith,WA
中科院分区：
文献类型：
--
作者：
Smith,WA
烟草天蛾（Manduca sexta）的前胸腺通过涉及cAMP、蛋白磷酸化、蛋白合成和蜕皮类固醇（包括蜕皮激素和3-脱氢蜕皮激素）分泌增强的调节途径对促前胸腺激素（PTTH）作出反应。最近的研究表明，PTTH通过这种一般机制在整个第五龄幼虫中起作用，即，从幼虫到蛹的转变过程中然而，腺体在大小、类固醇生成能力以及与cAMP的合成、降解和细胞内作用相关的信号传导途径的元件方面经历发育变化。本综述描述了这样的变化，其可能的调节和后果，在一般情况下的内分泌事件的基础幼虫蛹变态在第五幼虫阶段。© 1995 Wiley利斯公司
The prothoracic glands of the tobacco hornworm,Manduca sexta, respond to prothoracicotropic hormone (PTTH) by a regulatory pathway involving cAMP, protein phosphorylation, protein synthesis, and enhanced secretion of ecdysteroids including ecdysone and 3‐dehydroecdysone. Recent investigations have revealed that PTTH acts by this general mechanism throughout the fifth larval instar, i.e., during the transition from larva to pupa. However, the glands undergo developmental changes in size, steroidogenic capacity, and in elements of the signalling pathway associated with synthesis, degradation, and intracellular action of cAMP. The present review describes such changes, and their possible regulation and consequences, in the general context of endocrine events underlying larval‐pupal metamorphosis during the fifth larval stage. © 1995 Wiley‐Liss, Inc.