The occurrence of nephrogenic diabetes insipidus in domestic fowl.
The occurrence of nephrogenic diabetes insipidus in domestic fowl.
复制标题
家禽肾性尿崩症的发生。
DOI：
10.1152/ajprenal.1989.256.4.f639
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Stallone,JN
中科院分区：
文献类型：
--
作者：
Braun,EJ;Stallone,JN
肾源性尿崩症（NDI）是由于肾脏无法浓缩尿液而引起的。NDI的根本原因是集合管对抗利尿激素的反应失败，然而，具体的肾小管缺陷还不清楚。在目前的调查中，在一个白色来航家禽品系中研究了一个明显的NDI病例。在该品系中，雄性每天的饮水量相当于其体重（BM）的24.0%（对照组5.4%），而雌性每天的饮水量相当于其BM的51.4%（对照组11.7%）。NDI禽类的血浆渗透压（mosmol/kgH 2 O）显著高于对照组（雄性319 +/- 1.7 vs. 311 +/- 1.2;雌性323 +/- 1.5 vs. 310 +/- 2.2）。NDI禽类的尿渗透压显著低于对照组（雄性90 +/- 6.2 vs. 524 +/- 4.0;雌性70 +/- 4.7 vs.无值）。作为对水剥夺的响应，NDI鸟的血浆渗透压比对照动物的血浆渗透压显著增加（在水剥夺48小时时，雄性357 +/- 2.5对331 +/- 1.2;雌性375 +/- 6.0对348 +/- 1.4）。雄性NDI鸟（9.9 +/- 0.7 microU/ml）和雌性NDI鸟（7.0 +/- 0.5 microU/ml）的基础血浆抗利尿激素（血浆精氨酸缩血管素，PAVT）水平分别比对照鸟高近6倍或近3倍。在响应水剥夺，PAVT的NDI和控制鸟类增加到类似的水平，虽然在PAVT水平的绝对增加是在NDI鸟类大幅减少。（250字处删节）
Nephrogenic diabetes insipidus (NDI) results from an inability of the kidney to concentrate the urine. The underlying cause of NDI is the failure of the collecting ducts to respond to antidiuretic hormone, however, the specific tubular defect is not well understood. In the present investigation an apparent case of NDI was studied in a strain of White Leghorn domestic fowl. In this strain, water intake of the males equaled 24.0% (controls 5.4%) of their body mass (BM) per day while that of the females equaled 51.4% (controls 11.7%) of their BM per day. Plasma osmolality (mosmol/kgH2O) of the NDI birds was significantly higher than that of controls (males 319 +/- 1.7 vs. 311 +/- 1.2; females 323 +/- 1.5 vs. 310 +/- 2.2). Urine osmolality of NDI birds was substantially lower than that of controls (males 90 +/- 6.2 vs. 524 +/- 4.0; females 70 +/- 4.7 vs. no value). In response to water deprivation, plasma osmolality of the NDI birds increased more markedly than that of the control animals (males 357 +/- 2.5 vs. 331 +/- 1.2; females 375 +/- 6.0 vs. 348 +/- 1.4 at 48 h of water deprivation). Basal plasma antidiuretic hormone (plasma arginine vasotocin, PAVT) levels in male NDI birds (9.9 +/- 0.7 microU/ml) and in female NDI birds (7.0 +/- 0.5 microU/ml) were nearly sixfold or nearly threefold higher, respectively, than in control birds. In response to water deprivation, PAVT of both NDI and control birds increased to similar levels, although the absolute increases in PAVT levels were substantially less in NDI birds.(ABSTRACT TRUNCATED AT 250 WORDS)