Role of mTOR Signaling in Tumor Microenvironment: An Overview.
Role of mTOR Signaling in Tumor Microenvironment: An Overview.
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DOI：
10.3390/ijms19082453
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发表时间：
2018-08-19
影响因子：
5.6
通讯作者：
Ciuffreda L
中科院分区：
文献类型：
--
作者：
Conciatori F;Bazzichetto C;Falcone I;Pilotto S;Bria E;Cognetti F;Milella M;Ciuffreda L
雷帕霉素靶蛋白（mTOR）通路通过整合多种外源性信号，包括肿瘤微环境（TME）中各种环境输入，来调控主要过程。近年来，人们已经充分认识到癌细胞与其肿瘤微环境共存并共同进化，而肿瘤微环境常常与耐药性有关。mTOR通路调节基质与肿瘤之间的相互作用，从而影响肿瘤免疫和血管生成。mTOR信号的激活与这些促癌的细胞过程相关，这使得mTOR成为新的联合疗法的一个有前景的靶点。这篇综述强调了mTOR信号在肿瘤微环境各要素的特性及活性中的作用，以及它们在癌症免疫治疗中的意义。
The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME’s elements and their implications in cancer immunotherapy.
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影响因子：
5.2
作者：
Conciatori F;Ciuffreda L;Bazzichetto C;Falcone I;Pilotto S;Bria E;Cognetti F;Milella M
通讯作者：
Milella M
影响因子：
4
作者：
Apte MV;Pirola RC;Wilson JS
通讯作者：
Wilson JS
影响因子：
11.2
作者：
Ahmad, Shamim;Abu-Eid, Rasha;Khleif, Samir N.
通讯作者：
Khleif, Samir N.
影响因子：
8
作者：
Dong, Y.;Richards, J-A E.;Wajapeyee, N.
通讯作者：
Wajapeyee, N.
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi