Control of foreign Ag‐specific Ab responses by Treg and Tfr
Control of foreign Ag‐specific Ab responses by Treg and Tfr
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DOI：
10.1111/imr.12888
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发表时间：
2020-06
影响因子：
8.7
通讯作者：
J. Wing;Ee Lyn Lim;S. Sakaguchi
中科院分区：
文献类型：
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作者：
J. Wing;Ee Lyn Lim;S. Sakaguchi
表达转录因子Foxp 3的调节性T细胞（Regulatory T cells，Tcells）在包括体液免疫调节在内的免疫稳态控制中起关键作用。最近，人们已经清楚地认识到，Tfos的一个专门的子集，T-滤泡调节细胞（Tfr），在控制T-滤泡辅助细胞（Tfh）细胞驱动的生发中心（GC）反应中具有特殊的作用。在Tfh接收到类似的分化信号后，Tfr获得特征性趋化因子受体和转录因子（如CXCR 5和BCL 6）的表达，使其能够进入B-细胞卵泡并进行原位抑制。似乎很清楚，Tfr对于预防自身免疫抗体诱导至关重要。然而，它们在控制外源抗原特异性抗体应答中的作用似乎更复杂，各种报告表明Tfr功能抑制后抗原特异性抗体应答增加或减少。由于它们是最近发现的，我们对Tfr的形成和功能的理解仍然存在许多空白。在这篇综述中，我们讨论了我们目前的知识，在体液免疫的背景下，TFR和TFR，以及如何这些细胞可能被操纵，以更好地控制疫苗反应。
Regulatory T cells (Tregs) expressing the transcription factor Foxp3 play a critical role in the control of immune homeostasis including the regulation of humoral immunity. Recently, it has become clear that a specialized subset of Tregs, T‐follicular regulatory cells (Tfr), have a particular role in the control of T‐follicular helper (Tfh) cell‐driven germinal center (GC) responses. Following similar differentiation signals as received by Tfh, Tfr gain expression of characteristic chemokine receptors and transcription factors such as CXCR5 and BCL6 allowing them to travel to the B‐cell follicle and deliver in situ suppression. It seems clear that Tfr are critical for the prevention of autoimmune antibody induction. However, their role in the control of foreign antigen‐specific antibody responses appears more complex with various reports demonstrating either increased or decreased antigen‐specific antibody responses following inhibition of Tfr function. Due to their recent discovery, our understanding of Tfr formation and function still has many gaps. In this review, we discuss our current knowledge of both Tregs and Tfr in the context of humoral immunity and how these cells might be manipulated in order to better control vaccine responses.