A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome.
A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome.
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DOI：
10.1155/2014/967946
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发表时间：
2014
影响因子：
--
通讯作者：
Hossain MZ
中科院分区：
文献类型：
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作者：
Hasan MM;Akter R;Ullah MS;Abedin MJ;Ullah GM;Hossain MZ
新流行的中东呼吸综合征（MERS）是由一种名为MERS-CoV的人类冠状病毒引起的，全球病死率约为30%。我们正在研究潜在的抗MERS-CoV的抗病毒治疗方法，通过使用宿主microRNA（miRNAs）来下调病毒基因表达以抑制病毒复制。我们从MERS-CoV基因组的11个潜在发夹序列中计算预测了13个潜在的细胞miRNA。我们的研究提供了一个有趣的假设，即hsa-miR-628- 5 p，hsa-miR-6804- 3 p，hsa-miR-4289，hsa-miR-208 a-3 p，hsa-miR-510- 3 p，hsa-miR-18 a-3 p，hsa-miR-329- 3 p，hsa-miR-548 ax，hsa-miR-3934- 5 p，hsa-miR-4474- 5 p，hsa-miR-7974，hsa-miR-6865- 5 p，和hsa-miR-342- 3 p，将是针对MERS-CoV感染的抗病毒治疗剂。
The new epidemic Middle East Respiratory Syndrome (MERS) is caused by a type of human coronavirus called MERS-CoV which has global fatality rate of about 30%. We are investigating potential antiviral therapeutics against MERS-CoV by using host microRNAs (miRNAs) which may downregulate viral gene expression to quell viral replication. We computationally predicted potential 13 cellular miRNAs from 11 potential hairpin sequences of MERS-CoV genome. Our study provided an interesting hypothesis that those miRNAs, that is, hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, hsa-miR-3934-5p, hsa-miR-4474-5p, hsa-miR-7974, hsa-miR-6865-5p, and hsa-miR-342-3p, would be antiviral therapeutics against MERS-CoV infection.