Haemodynamic changes in insulin-induced hypoglycaemia in normal man
Haemodynamic changes in insulin-induced hypoglycaemia in normal man
复制标题
正常人胰岛素引起的低血糖的血流动力学变化
DOI：
10.1007/bf00266031
复制
发表时间：
1984
期刊：
影响因子：
8.2
通讯作者：
M. Suzuki
中科院分区：
文献类型：
--
作者：
J. Hilsted;F. Bonde;M. Nørgaard;M. Greniman;N. Christensen;H. Parving;M. Suzuki
血液动力学变量（血浆容量，心率，血压，心输出量，每搏输出量，肺组织体积，总外周血管阻力，肝内脏血管阻力，下肢血管阻力和血浆儿茶酚胺）之前和之后在7名健康男性胰岛素诱导的低血糖进行了测量。血浆容量在血糖最低点时显著降低（平均降低222±41 ml），随后在30分钟内增加至低血糖前值。心输出量因低血糖而增加（平均增加2.8±0.61/min）。心输出量的早期上升主要是由于心率增加，但后来主要是由于每搏输出量增加。由于肺组织体积恒定，观察到的心输出量变化不太可能是由于Frank-Starling机制，而是由于交感-肾上腺活性增加。总外周血管阻力以及下肢血管阻力下降，而肝内脏血管阻力不受影响。因此，胰岛素诱导的低血糖对循环有明显的一过性影响。
Haemodynamic variables (plasma volume, heart rate, blood pressure, cardiac output, stroke volume, pulmonary tissue volume, total peripheral vascular resistance, hepato-splanchnic vascular resistance, lower extremity vascular resistance and plasma catecholamines) were measured before and after insulin-induced hypoglycaemia in seven healthy men. Plasma volume decreased significantly at the nadir of glucose (mean decrease 222±41 ml) and subsequently increased to pre-hypoglycaemic values within 30 min. Cardiac output increased in response to hypoglycaemia (mean increase 2.8±0.61/min). The early rise in cardiac output was primarily due to an increase in heart rate, but later mainly due to increased stroke volume. Since pulmonary tissue volume was constant, the observed changes in cardiac output are unlikely to be due to a Frank-Starling mechanism but rather to increased sympatho-adrenal activity. Total peripheral vascular resistance as well as lower extremity vascular resistance decreased, whereas hepato-splanchnic vascular resistance was unaffected. Thus insulin-induced hypoglycaemia has marked transient effects on the circulation.