Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
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DOI：
10.1038/nn1075
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发表时间：
2003-07-01
影响因子：
25
通讯作者：
Matthews, PM
中科院分区：
文献类型：
--
作者：
Behrens, TEJ;Johansen-Berg, H;Matthews, PM
关于人类大脑中解剖连接的证据很少，主要基于有限的死后观察。弥散张量成像以前曾被用于定义活体人脑中的大白质束，但这项技术在追踪灰质通路方面的成功有限。在这里，我们确定了特定的人类丘脑和皮质之间的联系，使用一种新的概率纤维束成像算法与扩散成像数据。丘脑灰质皮质连接模式的基础上分类显示不同的亚区，其位置对应于以前在组织学研究中所描述的核。我们在丘脑和皮层之间发现的联系与非人类灵长类动物的联系相似，并且在个体之间是可重复的。我们的研究结果提供了第一个定量的证明，可靠的推断人类灰质结构之间的解剖连接，使用扩散数据和第一个基于连接的分割灰质。
Evidence concerning anatomical connectivities in the human brain is sparse and based largely on limited post-mortem observations. Diffusion tensor imaging has previously been used to define large white-matter tracts in the living human brain, but this technique has had limited success in tracing pathways into gray matter. Here we identified specific connections between human thalamus and cortex using a novel probabilistic tractography algorithm with diffusion imaging data. Classification of thalamic gray matter based on cortical connectivity patterns revealed distinct subregions whose locations correspond to nuclei described previously in histological studies. The connections that we found between thalamus and cortex were similar to those reported for non-human primates and were reproducible between individuals. Our results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.