The isolation and characterization of a new tetrahydroprotoberberine alkaloid from Corydalis clarkei.
The isolation and characterization of a new tetrahydroprotoberberine alkaloid from Corydalis clarkei.
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克氏紫堇中一种新的四氢原小檗碱生物碱的分离和表征。
DOI：
10.1021/np50041a015
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发表时间：
1985
影响因子：
5.1
通讯作者：
Cook,JM
中科院分区：
文献类型：
--
作者：
Rothera,MA;Wehrli,S;Cook,JM
克氏紫堇的甲醇提取物产生了两种四氢原小檗碱生物碱，它们具有以前仅在酪氨酸中观察到的不寻常的 1, 2- 和 9, 10-四氧化取代模式 (10)。这些生物碱已被鉴定为酪氨酸 (1) 和新的生物碱克拉尼定 (2)。两种生物碱的 H 和 13C-nmr 位移已使用 2-D nmr 明确指定。通过将 2 的 H 和 13C 核磁共振谱与酪氨酸的谱图进行比较，并结合其他光谱证据，阐明了 2 的结构。 克拉氏堇是第一个在 1984 年夏天采集的多种藏药用植物 (1, 2) (3)，并进行了化学研究。据称，它与其他植物一起用于治疗“高血压”(4)，尽管迄今为止，尚未获得其有效性的证据。它是生长在喜马拉雅地区海拔 12,000-15,000 英尺的约 25 种紫堇属物种之一 (5, 6)。
The MeOH extract of Corydalis clarkei Prain yielded two tetrahydroprotoberberine alkaloids that bear the unusual 1, 2-and 9, 10-tetraoxygenated substitution pattern observed previouslyonly in caseanidine (10). The alkaloids have been identified as caseanidine (1) and the new alkaloid, clarkeanidine (2). The* H-and l3C-nmr shifts of both alkaloids have been assigned unambiguously using 2-D nmr. The elucidation of the structure of 2 was achieved by comparison of the* H-and 13C-nmr spectra of 2 with those of caseanidine coupled with addi-tional spectroscopic evidence.Corydalis clarkei Prain is the first of a number of Tibetan medicinal plants (1, 2) col-lected in the summer of 1984 (3) to be investigated chemically. In conjunction with other plants, it is purportedly employed to treat “high blood pressure”(4), although as yet, no evidence for its effectiveness has been obtained. It is one of approximately 25 Corydalis species that grow in the Himalayan region at an altitude of 12,000-15,000 feet (5, 6).