A family of tissue-specific resistin-like molecules
A family of tissue-specific resistin-like molecules
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DOI：
10.1073/pnas.98.2.502
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发表时间：
2001-01-16
影响因子：
11.1
通讯作者：
Lazar, MA
中科院分区：
文献类型：
--
作者：
Steppan, CM;Brown, EJ;Lazar, MA
我们在啮齿类动物和人类中鉴定出了一系列抵抗素样分子（RELM）。抵抗素是脂肪细胞产生的一种激素。 RELM α 是一种分泌蛋白，其组织分布有限，在脂肪组织中含量最高。另一个家族成员 RELM beta 是一种仅在小鼠和人类的胃肠道，特别是结肠中表达的分泌蛋白。 RELM beta 基因表达在增殖性上皮细胞中最高，在肿瘤中显着增加，表明其在肠道增殖中发挥作用。抵抗素和 RELM 具有相同的半胱氨酸组成和其他特征。因此，RELM 与抵抗素一起构成了一类组织特异性信号分子。
We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells. RELM alpha is a secreted protein that has a restricted tissue distribution with highest levels in adipose tissue. Another family member, RELM beta, is a secreted protein expressed only in the gastrointestinal tract, particularly the colon, in both mouse and human. RELM beta gene expression is highest in proliferative epithelial cells and is markedly increased in tumors, suggesting a role in intestinal proliferation. Resistin and the RELMs share a cysteine composition and other signature features. Thus, the RELMs together with resistin comprise a class of tissue-specific signaling molecules.