Choclo virus infection in the Syrian golden hamster
Choclo virus infection in the Syrian golden hamster
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DOI：
10.4269/ajtmh.2008.78.669
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发表时间：
2008-04-01
影响因子：
3.3
通讯作者：
Fulhorst, Charles F.
中科院分区：
文献类型：
--
作者：
Eyzaguirre, Eduardo J.;Milazzo, Mary Louise;Fulhorst, Charles F.
安第斯山脉病毒和Choclo病毒是汉坦病毒肺综合征的病原体。仓鼠中的安第斯山脉病毒几乎总是引起一种在病理学上与致死性汉坦病毒肺综合征难以区分的疾病。本研究的目的是评估Choclo病毒对仓鼠的致病性。18只感染Choclo病毒的仓鼠均未出现任何疾病症状。在接种后第7、9、11、13和16天处死的10只动物的肺中或在接种后第28天处死的8只动物的肺中未发现炎症或水肿的证据;然而在第7，9，11，接种后13例。这些结果表明，在感染安第斯山脉病毒的仓鼠中，肺组织的微血管中的感染单独不会导致危及生命的肺水肿。
Andes virus and Choclo virus are agents of hantavirus pulmonary syndrome. Andes virus in hamsters almost always causes a disease that is pathologically indistinguishable from fatal hantavirus pulmonary syndrome. The purpose of this study was to assess the pathogenicity of Choclo virus in hamsters. None of 18 hamsters infected with Choclo virus exhibited any symptom of disease. No evidence of inflammation or edema was found in the lungs of the 10 animals killed oil days 7, 9, 11, 13, and 16 post-inoculation or in the lungs of the 8 animals killed on day 28 post-inoculation; however, hantavirus antigen was present in large numbers of endothelial cells in the microvasculature of the lungs of the animals killed on days 7, 9, 11, and 13 post-inoculation. These results suggest that infection in the microvasculature of lung tissue alone does not result in the life-threatening pulmonary edema in hamsters infected with Andes virus.