Effects of octreotide on responses to colorectal distension in the rat
Effects of octreotide on responses to colorectal distension in the rat
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DOI：
10.1136/gut.48.5.676
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发表时间：
2001-05
期刊：
影响因子：
24.5
通讯作者：
X. Su;M. B. Burton;G. Gebhart
中科院分区：
文献类型：
--
作者：
X. Su;M. B. Burton;G. Gebhart
背景与目的生长抑素类似物奥曲肽对内脏痛的镇痛作用涉及外周机制。我们评估了奥曲肽对大鼠伤害性结直肠扩张反应的影响。方法：在行为学研究中，在静脉或鞘内注射奥曲肽之前和之后，评估对结直肠扩张的升压和肌电反应。在盆神经传入纤维记录，机械敏感纤维支配结肠有害的结直肠扩张（80毫米汞柱，30秒）之前和之后奥曲肽进行了测试。结果奥曲肽静脉给药对正常结肠或醋酸炎症结肠的结直肠扩张反应无效，但鞘内给药则减弱了结直肠扩张反应。奥曲肽在较宽的剂量范围内（0.5 μg/kg至2.4 mg/kg）给药，未改变传入纤维对未处理或乙酸或酵母多糖处理的结肠中有害性结肠直肠扩张的反应。结论：奥曲肽对大鼠内脏伤害性感受无外周（盆神经）调节作用。奥曲肽在该内脏伤害感受模型中的抗伤害感受作用是通过中枢部位的作用介导的。
BACKGROUND AND AIMS It has been suggested that the analgesic effect of the somatostatin analogue octreotide in visceral pain involves peripheral mechanisms. We evaluated the effect of octreotide on responses to noxious colorectal distension in rats. METHODS In a behavioural study, pressor and electromyographic responses to colorectal distension were evaluated before and after intravenous or intrathecal administration of octreotide. In pelvic nerve afferent fibre recordings, responses of mechanosensitive fibres innervating the colon to noxious colorectal distension (80 mm Hg, 30 seconds) were tested before and after octreotide. RESULTS Octreotide was ineffective in attenuating responses to colorectal distension in either normal or acetic acid inflamed colon when administered intravenously but attenuated responses when given intrathecally. Administration of octreotide over a broad dose range (0.5 μg/kg to 2.4 mg/kg) did not alter responses of afferent fibres to noxious colorectal distension in untreated, or acetic acid or zymosan treated colons. CONCLUSIONS In the rat, octreotide has no peripheral (pelvic nerve) modulatory action in visceral nociception. The antinociceptive effect of octreotide in this model of visceral nociception is mediated by an action at central sites.