Diurnal and seasonal changes in semen quality of men in subfertile partnerships
Diurnal and seasonal changes in semen quality of men in subfertile partnerships
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DOI：
10.1080/07420528.2018.1483942
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发表时间：
2018-06
影响因子：
2.8
通讯作者：
M. Xie;K. S. Utzinger;K. Blickenstorfer;B. Leeners
中科院分区：
文献类型：
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作者：
M. Xie;K. S. Utzinger;K. Blickenstorfer;B. Leeners
摘要 昼夜节律和昼夜节律不仅影响环境，还影响人类生理。随着越来越多的夫妇与不孕作斗争，从而对成功辅助生殖的需求不断增加，我们研究的目的是评估昼夜节律和昼夜节律及其与精液质量的关系。 1994年至2015年间，苏黎世大学医院生殖内分泌科男科实验室采集了7 068名男性的12 245份精液样本，对精子浓度、精子总数、前行活力和正常形态进行了统一分析。在这四个参数的基础上，我们回顾性地检查了精液质量的昼夜和年度变化。 Mann-Whitney U 检验和多元线性回归分析用于统计评估。清晨7点30分之前采集的精液样本，精子浓度、精子总数和正常形态最高，均具有统计学意义。渐进运动没有显示出任何基于昼夜节律的显着改变。此外，春季精子浓度和精子总数显着增加，夏季显着下降。正常形态的百分比在夏季最高。对于渐进运动，无法证明显着的季节性变化。男性精液质量随昼夜节律和昼夜节律而变化。在精液质量最高的清晨采集精液可用于提高自然生育力以及辅助生殖产生的生育力。
ABSTRACT Circadian and circannual rhythms influence not only the environment, but also human physiology. In times of increasing numbers of couples struggling with infertility, and thus increasing demand for successful assisted reproduction, the aim of our study was to evaluate circadian and circannual rhythms and their association with semen quality. A total of 12 245 semen samples from 7068 men, collected at the andrology laboratory of the Department of Reproductive Endocrinology, University Hospital Zurich, between 1994 and 2015, were uniformly analysed in terms of sperm concentration, total sperm count, progressive motility and normal morphology. On the basis of these four parameters, we retrospectively examined the circadian and circannual changes of semen quality. The Mann–Whitney U test and multiple linear regression analysis were used for the statistical evaluation. The semen samples collected in the early morning before 7:30 a.m. showed the highest levels in sperm concentration, total sperm count and normal morphology, all with statistical significance. Progressive motility did not show any significant alterations based on circadian rhythm. Furthermore, a significant increase in sperm concentration and total sperm count was found in spring, with significant decreases in the summer. The highest percentage of normal morphology was found in summer. For progressive motility, no significant seasonal variation could be demonstrated. Male semen quality varies with both circadian and circannual rhythms. Collection of semen in the early morning, where semen quality was highest, can be used to improve natural fertility as well as fertility resulting from assisted reproduction.