Imaging pain modulation in health and disease
Imaging pain modulation in health and disease
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DOI：
10.1097/wco.0b013e328259c34d
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发表时间：
2007-08-01
影响因子：
4.8
通讯作者：
Buechel, Christian
中科院分区：
文献类型：
--
作者：
Bingel, Ulrike;Schoell, Eszter;Buechel, Christian
在这篇综述中，我们讨论了疼痛影像学研究的最新进展。我们关注健康中枢神经系统中内源性疼痛控制机制的参与，以及该系统失败对慢性疼痛状态的潜在贡献。最近的研究发现，痛觉信息加工和相关的痛觉受大量的亲痛觉和反痛觉调节。最近的研究表明，这种调制可以发生在上升信息处理的任何阶段。皮层网络，主要是内侧和额叶区域，结合特定的脑后核，似乎是内源性疼痛调节的关键参与者。最近来自功能和解剖神经影像学的研究结果支持这样一种观点，即亲和抗感觉机制的相互作用的改变可能有助于慢性疼痛状态的发展或维持。在疼痛成像研究中额外使用药理学干预为研究疼痛调节机制提供了另一种工具。自上而下的疼痛调节依赖于皮层和皮层下结构。对相关电路及其实现机制的研究是当代疼痛领域神经科学研究的主要焦点，并将为慢性疼痛状态的预防和治疗提供新的见解。
Purpose of reviewIn this review, we discuss recent advances in pain imaging research. We focus on the involvement of endogenous pain control mechanisms in the healthy central nervous system and the potential contribution of failure within this system for chronic pain states.Recent findingsNociceptive information processing and related pain perception is subject to substantial pro and antinociceptive modulation. Recent studies demonstrate that this modulation can take place at any stage of ascending information processing. A network of cortical, predominantly mesial and frontal areas, in combination with specific brainstern nuclei, appear to be the key players in the context of endogenous pain modulation. Recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro and antinociceptive mechanisms may contribute to the development or maintenance of chronic pain states. The additional use of pharmacological intervention in pain imaging research provides an alternative tool for investigating mechanisms of pain modulation.SummaryTop-down pain modulation relies on both cortical and subcortical structures. Research on the involved circuitry, including the implemented mechanisms, is a major focus of contemporary neuroscientific research in the field of pain and will provide new insights into the prevention and treatment of chronic pain states.