Angiogenesis and ophthalmic disease.
Angiogenesis and ophthalmic disease.
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DOI：
10.1023/a:1009071601454
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发表时间：
1999-01-01
期刊：
影响因子：
9.8
通讯作者：
D'Amato, R A
中科院分区：
文献类型：
--
作者：
Adamis, A P;Aiello, L P;D'Amato, R A
眼部血管生成是发达国家大多数不可逆性失明的原因[1]。这种令人衰弱的并发症影响到所有年龄组，并表现为各种广泛存在的疾病，如沙眼、早产儿视网膜病变、糖尿病视网膜病变、新生血管性青光眼和年龄相关性黄斑变性。虽然许多相对罕见的疾病也表现出眼部血管生成，但本综述的目的将是简要总结我们目前对最具流行病学意义的疾病的临床和实验室结果的了解。我们还将描述有关眼部血管生成发病机制的现有概念。在这篇综述中，眼科文献中更常用的术语“新生血管”将被用来描述病理性新血管的发展，应该被认为是“血管生成”的同义词。
Ocular angiogenesis is responsible for the majority of irreversible blindness in the developed world [1]. This debilitating complication affects all age groups and characterizes such diverse and widespread diseases as trachoma, retinopathy of prematurity, diabetic retinopathy, neovascular glaucoma and age-related macular degeneration. Although numerous relatively rare conditions also exhibit ocular angiogenesis, the aim of this review will be to briefly summarize our current knowledge regarding the clinical and laboratory findings of the most epidemiologically significant diseases. We will also describe current concepts regarding the pathogenesis of ocular angiogenesis. In this review the term 'neovascularization', which is more prevalent in the ophthalmic literature, will be used to describe the development of pathological new vessels and should be considered synonymous with 'angiogenesis'.