Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor
Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor
复制标题
使用基于锑烯的表面等离子共振传感器对 miRNA 进行超灵敏检测
DOI：
10.1038/s41467-018-07947-8
复制
发表时间：
2019-01-03
影响因子：
16.6
通讯作者：
Bao, Qiaoliang
中科院分区：
文献类型：
--
作者：
Xue, Tianyu;Liang, Weiyuan;Bao, Qiaoliang
MicroRNA exhibits differential expression levels in cancer and can affect cellular transformation, carcinogenesis and metastasis. Although fluorescence techniques using dye molecule labels have been studied, label-free molecular-level quantification of miRNA is extremely challenging. We developed a surface plasmon resonance sensor based on two-dimensional nanomaterial of antimonene for the specific label-free detection of clinically relevant biomarkers such as miRNA-21 and miRNA-155. First-principles energetic calculations reveal that antimonene has substantially stronger interaction with ssDNA than the graphene that has been previously used in DNA molecule sensing, due to thanking for more delocalized 5s/5porbitals in antimonene. The detection limit can reach 10 aM, which is 2.3–10,000 times higher than those of existing miRNA sensors. The combination of not-attempted-before exotic sensing material and SPR architecture represents an approach to unlocking the ultrasensitive detection of miRNA and DNA and provides a promising avenue for the early diagnosis, staging, and monitoring of cancer.
