Cell polarization: From epithelial cells to odontoblasts
Cell polarization: From epithelial cells to odontoblasts
复制标题
DOI：
10.1016/j.ejcb.2018.11.003
复制
发表时间：
2019-01-01
影响因子：
6.6
通讯作者：
Liu, Xiaohua
中科院分区：
文献类型：
--
作者：
Chang, Bei;Svoboda, Kathy K. H.;Liu, Xiaohua
细胞极性识别细胞的不对称性。各种类型的细胞，包括成牙本质细胞和上皮细胞，极化以完成它们预定的功能。成牙本质细胞极化是牙齿发育和管状牙本质形成的前提和基本步骤。然而，目前对成牙本质细胞极化的了解非常有限，这极大地阻碍了再生牙髓学新方法的发展。与成牙本质细胞相比，上皮细胞极化在过去的几十年里得到了广泛的研究。从上皮细胞极化中获得的知识也适用于其他类型的细胞，考虑到极化的成牙本质细胞和上皮细胞在形态和成分特征上的显著相似之处，这一点尤其有用。在这篇综述中，我们首先讨论了上皮细胞极化的特点、关键调控因素和过程。接下来，我们将已知的成牙本质细胞极化与上皮细胞进行比较。最后，我们澄清了成牙本质细胞极化方面的知识空白，并提出了未来研究的方向，以填补空白，促进再生牙本质学的发展。
Cell polarity identifies the asymmetry of a cell. Various types of cells, including odontoblasts and epithelial cells, polarize to fulfil their destined functions. Odontoblast polarization is a prerequisite and fundamental step for tooth development and tubular dentin formation. Current knowledge of odontoblast polarization, however, is very limited, which greatly impedes the development of novel approaches for regenerative endodontics. Compared to odontoblasts, epithelial cell polarization has been extensively studied over the last several decades. The knowledge obtained from epithelia polarization has been found applicable to other cell types, which is particularly useful considering the remarkable similarities of the morphological and compositional features between polarized odontoblasts and epithelia. In this review, we first discuss the characteristics, the key regulatory factors, and the process of epithelial polarity. Next, we compare the known facts of odontoblast polarization with epithelial cells. Lastly, we clarify knowledge gaps in odontoblast polarization and propose the directions for future research to fill the gaps, leading to the advancement of regenerative endodontics.