Bacterial invasion of epithelial cells and spreading in periodontal tissue.
Bacterial invasion of epithelial cells and spreading in periodontal tissue.
复制标题
DOI：
10.1111/j.1600-0757.2009.00323.x
复制
发表时间：
2010-02
影响因子：
18.6
通讯作者：
Lamont RJ
中科院分区：
文献类型：
--
作者：
Tribble GD;Lamont RJ
牙龈下细菌微生物群的组成是牙周组织健康状况的关键决定因素。革兰氏阴性厌氧菌，如牙龈卟啉单胞菌是公认的牙周病原体，在慢性牙周炎患者的龈下沟中发现大量这种细菌（43）。然而，越来越多的证据表明，这些生物与宿主的关系远比仅仅作为病原体的关系复杂得多。革兰氏阴性厌氧菌经常出现在牙周健康个体的口腔中（23,44,92,121,127,128,170），尽管多年暴露于大量微生物负担中，但健康是人类牙龈最常见的状态。因此，牙周生物似乎与其宿主共同进化，以维持生态平衡，从而将对任何一方造成的伤害降到最低。只有当这种相互作用变得不平衡时，疾病才会随之而来，这种事件被称为生态灾难（83）。因此，像牙龈卟啉卟啉菌这样的生物体可能更准确地被定性为偶然的或适应宿主的病原体。在龈下腔室中，上皮细胞是生物定植的主要宿主界面；因此，牙龈上皮细胞和牙周细菌之间的相互作用将有助于定植的成功或失败，并维持宿主的健康或疾病。不可否认，在牙龈假单胞菌的情况下，生物体和牙龈上皮细胞之间存在着复杂的多线程关系，在最佳条件下，细菌和宿主细胞都对伴侣的存在做出反应和适应，以维持健康状态。如果这种关系受到干扰，例如由于细菌负担增加或不适当的免疫反应，就会引发牙周病（13）。
The composition of the subgingival bacterial microbiota is a critical determinant in the health status of periodontal tissues. Gram-negative anaerobes such as Porphyromonas gingivalis are well-established periodontal pathogens, and high numbers of these bacteria are found in the subgingival sulcus of patients with chronic periodontitis (43). However, a burgeoning pool of evidence indicates that these organisms have a far more complex relationship with the host than merely as pathogens. Gram-negative anaerobes are frequently present in the oral cavity of periodontally healthy individuals (23, 44, 92, 121, 127, 128, 170), and indeed health is the most common status of the human gingiva despite years of exposure to a large microbial burden. Periodontal organisms thus appear to have co-evolved with their host to maintain an ecologically balanced association whereby minimal harm is inflicted on, or by, either party. Disease will only ensue when this interaction becomes unbalanced, an event that has been termed an ecological catastrophe (83). Organisms such as P. gingivalis may thus be more accurately characterized as accidental, or host-adapted, pathogens.In the subgingival compartment, epithelial cells represent a major host interface for colonizing organisms; hence, the interaction between gingival epithelial cells and periodontal bacteria will contribute to the success or failure of colonization, and to the maintenance of health or disease in the host. Undeniably, in the case of P. gingivalis, an intricate and multithreaded relationship exists between the organism and gingival epithelial cells, which, under optimal conditions, results in stable cohabitation, with both bacteria and host cells responding and adapting to the presence of their partner to maintain a state of health. In the event that this relationship becomes perturbed, for example because of an increase in bacterial burden or an inappropriate immune response, the periodontal disease process can be initiated (13).
登录
查看更多内容
影响因子：
7.6
作者：
DeCarlo, AA;Windsor, LJ;BirkedalHansen, H
通讯作者：
BirkedalHansen, H
影响因子：
3.2
作者：
Chen, T;Hosogi, Y;Duncan, MJ
通讯作者：
Duncan, MJ
影响因子：
5.6
作者：
Andrian, E;Grenier, D;Rouabhia, M
通讯作者：
Rouabhia, M
DOI：
10.1006/bbrc.1999.1075
发表时间：
1999-08-11
影响因子：
3.1
作者：
Banbula, A;Bugno, M;Potempa, J
通讯作者：
Potempa, J
影响因子：
3.4
作者：
Belton, CM;Izutsu, KT;Lamont, RJ
通讯作者：
Lamont, RJ