Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment
Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment
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DOI：
10.1107/s0909049510037076
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发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
Urade, Yoshihiro
中科院分区：
文献类型：
--
作者：
Tanaka, Hiroaki;Tsurumura, Toshiharu;Urade, Yoshihiro
人造血前列腺素合成酶是治疗过敏和炎症较好的靶酶之一，在微重力条件下用22种抑制剂和3种无抑制剂的条件结晶。大多数空间生长的晶体表现出比陆地生长的晶体更好的X射线衍射图，表明微重力环境对蛋白质结晶的优势，特别是在这种蛋白质的情况下。
Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a microgravity environment on protein crystallization, especially in the case of this protein.