Tissue doses of ethylene oxide in cigarette smokers determined from adduct levels in hemoglobin.
Tissue doses of ethylene oxide in cigarette smokers determined from adduct levels in hemoglobin.
复制标题
根据血红蛋白加合物水平确定吸烟者体内环氧乙烷的组织剂量。
作者：
M. Törnqvist;S. Osterman;A. Kautiainen;S. Jensen;P. Farmer;L. Ehrenberg
血红蛋白加合物的测定是监测组织中致癌物剂量的有效方法。这种方法为风险估计和识别先验未知的环境致癌物提供了基础。本文介绍了一种新的血红蛋白加合物分析方法在吸烟者和非吸烟者中的应用。结果表明，吸烟者Hb的N-末端缬氨酸的羟乙基化水平升高，这与作为来源的烟雾中的乙烯定量相容。来自吸入乙烯的环氧乙烷的组织剂量的大小表明，该因素是吸烟相关癌症风险的主要贡献者。
Determination of adducts to hemoglobin (Hb) is a useful approach for monitoring tissue doses of ultimate carcinogens. This approach provides a basis for both risk estimation and for the identification of a priori unknown environmental carcinogens. This paper describes the application of a new method for the analyses of Hb adducts to cigarette smokers and non-smokers. The results demonstrate a raised level of hydroxyethylation of N-terminal valine of Hb of smokers that is quantitatively compatible with ethene in the smoke being the source. The magnitude of the tissue doses of ethylene oxide originating from inhaled ethene suggests that this factor is a major contributor to smoking-associated cancer risk.