A dynamic liver culture system: a tool for studying chemical biotransformation and toxicity.
A dynamic liver culture system: a tool for studying chemical biotransformation and toxicity.
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动态肝脏培养系统：研究化学生物转化和毒性的工具。
DOI：
10.1007/978-3-642-72558-6_3
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Brendel,K
中科院分区：
文献类型：
--
作者：
Sipes,IG;Fisher,RL;Smith,PF;Stine,ER;Gandolfi,AJ;Brendel,K
在过去几年中，使用整个动物系统进行毒性试验已被体外试验系统广泛补充。这种系统，通过不断改进和扩大的多功能性作为研究工具，有很大的希望，更迅速和更便宜的评价新的和现有的化学品和药物的潜在毒性。此外，体外系统可用于阐明化学品诱导组织损伤的机制。在体外系统中，实验系统可以严格控制。体外系统还提供了探索异生物质生物转化的途径和速率的机会，这是一个通常决定所观察到的毒性的性质和程度的因素。
The use of whole animal systems for toxicity testing has been extensively supplemented during the past several years with in vitro test systems. Such systems, through continued improvement and expanded versatility as research tools, hold great promise for the more rapid and less expensive evaluation of the potential toxicity of new and existing chemicals and pharmaceuticals. In addition, in vitro systems are useful in the elucidation of the mechanisms by which chemicals induce tissue damage. In in vitro systems the experimental system can be rigidly controlled. In vitro systems also provide opportunities to explore routes and rates of xenobiotic biotransformation, a factor which often determines the nature and degree of the observed toxicity.