Cancer stem cell markers as potential targets for epithelial cancers.
Cancer stem cell markers as potential targets for epithelial cancers.
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DOI：
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发表时间：
2011-11
影响因子：
0.6
通讯作者：
Venkateshwar Madka;C. Rao
中科院分区：
文献类型：
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作者：
Venkateshwar Madka;C. Rao
近年来，肿瘤起始细胞（通常称为癌症干细胞）在肿瘤发展中的作用和新的癌症干细胞/肿瘤起始细胞标记物的可用性为理解它们在开发新的靶向分子中的作用提供了新的竞技场。识别和理解肿瘤干细胞（CSC）/肿瘤起始细胞（TIC）在肿瘤发展中的相关性并设计适当的CSC和TIC消除策略是重要的，这对未来的癌症预防和治疗至关重要。本文综述了肿瘤干细胞的各种标志物及其作为上皮癌防治靶点的研究进展。
In recent years, the role of tumor-initiating cells (popularly known as cancer stem cells) in tumor development and availability of novel cancer stem cell/tumor initiating cell markers promises a new arena in understanding their role in developing novel targeted molecules. It is important to identify and understand the relevance of cancer stem cells (CSC)/tumor initiating cells (TIC) in tumor development and to design appropriate strategies for CSCs and TICs elimination, which is crucial to future cancer prevention and treatment. In this review, we attempt to define various potential markers of cancer stem cells and potential exploration as therapeutic targets for epithelial cancer prevention and treatment.