CORRELATED RESPONSE IN THE DEVELOPMENTAL CHOREOGRAPHIES OF THE MOUSE MANDIBLE TO SELECTION FOR BODY-COMPOSITION
CORRELATED RESPONSE IN THE DEVELOPMENTAL CHOREOGRAPHIES OF THE MOUSE MANDIBLE TO SELECTION FOR BODY-COMPOSITION
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DOI：
10.1111/j.1558-5646.1990.tb05947.x
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发表时间：
1990-05-01
期刊：
影响因子：
3.3
通讯作者：
HAWKINSBROWN, D
中科院分区：
文献类型：
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作者：
ATCHLEY, WR;COWLEY, DE;HAWKINSBROWN, D
对小鼠下颌骨的11个性状进行了13代胖瘦百分比选择的相关反应研究。选用高脂（HF）、低脂（LF）、高瘦（HL）、低瘦（LL） 5个选育品系和随机选择的对照品系（RC）。RC菌株的个体发育模式可作为评估定向选择的发育后果的模型。选择系统地改变了选择系相对于对照品系的下颌骨生长模式。此外，选择显著改变了这些性状之间的年龄特异性表型协方差。在HF品系中，大多数性状在12周龄时完成下颌骨的生长。在其他选定的菌株中，特别是LF和LL，在12至15周龄之间出现显著的生长突增。下颌骨生长模式的变化在下颌骨的最终形态中产生了显著的差异。由于生长模式的变化，菌株之间的差异本身在出生后的不同年龄也有所不同。表型相似的毒株，即HF和LL或LF和HL，表现出不同但相关的分化模式。多元统计分析表明，这些性状的时间应变差异是多维的。
The correlated response to 13 generations of selection for percent fatness and leanness is investigated in 11 mandible traits in mice. Five selection lines are examined including high fat (HF), low fat (LF), high lean (HL), low lean (LL) and randomly selected control strain (RC). The ontogenetic patterns of growth in the RC strain serve as a model to evaluate the developmental consequences of directional selection. Selection had systematically altered the patterns of mandible growth in selection lines relative to the control strain. Further, selection has significantly altered the age-specific phenotype covariance among these traits. In the HF strain, growth in the mandible is completed by 12 weeks of age for most traits. In other selected strains, notably LF and LL, there is a significant growth spurt that occurs between 12 and 15 weeks of age. Changes in the patterns of mandibular growth produce significant differences among strains in the final form of the mandible. Because of the changes in the patterns of growth, the difference among strains are themselves shown to vary at different postnatal ages. The phenotypically similar strains, i.e., HF and LL or LF and HL, show different but correlated patterns of divergence. Multivariate statistical analyses suggest that the temporal strain differences in these traits are multidimensional.