Cantalasaponin-1, a novel spirostanol bisdesmoside from Agave Cantala
Cantalasaponin-1, a novel spirostanol bisdesmoside from Agave Cantala
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DOI：
10.1021/np50039a007
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发表时间：
1985-05
影响因子：
5.1
通讯作者：
O. Sati;G. Pant;K. Miyahara;T. Kawasaki
中科院分区：
文献类型：
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作者：
O. Sati;G. Pant;K. Miyahara;T. Kawasaki
Cantalasaponin-1（1），一种新的螺甾烷醇双桥糖甙（第一个基于红光苷元的糖苷），已从龙舌兰（AgaveCantata）根茎的甲醇提取物中分离得到，并借助于fdms，fabms，eims，龙舌兰属植物具有杀鱼和抗癌活性。两种基于海柯皂苷的糖苷，分别来自龙舌兰的叶（3）和果实（4），以及一种来自龙舌兰叶的氯代皂苷二葡萄糖苷（5）。已被报道。我们已经预先报道了（6）从乙酸乙酯提取物中提取的甾体皂苷元，这里描述了从该植物根茎的甲醇提取物中分离和表征的Cantalasaponin-1（1），一种新的螺甾烷醇双链糖苷（第一个基于红光苷元的糖苷）; 1已被发现对JTC-26（源自人宫颈癌）具有细胞毒性（7）。
Cantalasaponin-1 (1), a novel spirostanol bisdesmoside (the first hongguanggenin-based glycoside), has been isolated from the methanolic extract of the rhizomes of Agave cantata and characterized as 3, 6-di-0-[3-D-glucopyranosyl]-(2 5 R)-spirostan-3ß, 6, 23-1 with the help of fdms, fabms, eims,'H nmr and 13C nmr.Agave plants exhibit piscicidal (1) and anticancer (2) properties. Two hecogenin-based glycosides, one each from the leaves (3) and fruits (4), and a chlorogenin diglucoside (5) from the leaves of Agave cantala Roxb. have been reported. We have pre-viously reported (6) steroidalsapogenins from the EtOAc extract, and here the isolation and characterization of cantalasaponin-1 (1), a new spirostanol bisdesmoside (the first hongguanggenin-based glycoside) from the methanolic extract of the rhizomes of this plant is described; 1 has been found to possess cytotoxicity against JTC-26 (originating from human cervical carcinoma)(7).