Bone Regeneration Based on Tissue Engineering Conceptions - A 21st Century Perspective.
Bone Regeneration Based on Tissue Engineering Conceptions - A 21st Century Perspective.
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DOI：
10.4248/br201303002
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发表时间：
2013-09
期刊：
影响因子：
12.7
通讯作者：
Hutmacher DW
中科院分区：
文献类型：
--
作者：
Henkel J;Woodruff MA;Epari DR;Steck R;Glatt V;Dickinson IC;Choong PF;Schuetz MA;Hutmacher DW
骨组织工程在再生医学领域的作用在过去的二十年里一直是实质性研究的主题。技术进步改进了骨科植入物和骨重建的外科技术。然而，由于可用自体材料的匮乏和供骨部位的发病率，重建骨的外科技术的改进一直受到限制。生物材料发展的最新进展为骨移植提供了有吸引力的替代方案，扩大了恢复受损骨的形态和功能的手术选择。具体地说，已经开发了新型生物活性(第二代)生物材料，其特征是对宿主组织环境的可控作用和反应，同时表现出可控的化学分解和吸收，最终通过再生组织来替代。未来的生物材料(第三代)不仅具有骨传导性，而且具有骨诱导性，即通过结合组织工程和原位组织再生方法来刺激宿主组织的再生，并专注于新的应用。这些技术将为组织再生和修复带来新的可能性。目前，无论是创伤后、退行性、肿瘤性或先天性/发育“起源”的复杂骨缺损，未来可能被用作骨移植的组织工程化构建物都需要骨重建以确保结构和功能的完整性。利用细胞、支架和生物活性因子的组合来设计功能骨是一种很有前途的策略，也是未来杂化材料领域发展的一个独特之处，因为杂化材料能够表现出合适的仿生和力学性能。这篇综述将讨论这一领域的最新进展，以及我们对未来几代骨再生概念的期待。
The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental “origin” require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.