Stimulus novelty differentially affects attentional allocation in PTSD
Stimulus novelty differentially affects attentional allocation in PTSD
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DOI：
10.1016/s0006-3223(99)00258-9
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发表时间：
2000-05-15
影响因子：
10.6
通讯作者：
Deldin, P
中科院分区：
文献类型：
--
作者：
Kimble, M;Kaloupek, D;Deldin, P
背景：本研究调查了 39 名越战老兵的注意力分配情况，其中 25 名患有创伤后应激障碍，14 名没有患有创伤后应激障碍，评估了三音和新奇“奇怪”任务期间的 P300 振幅和潜伏期。方法：三音奇怪任务由三种刺激组成：频繁音调 (85%)、罕见目标音调 (75%) 和罕见干扰音调 (75%)。新奇古怪的任务与三音调任务相同，只是罕见的分散注意力的音调被不重复的新颖声音所取代（75%）。 结果：患有创伤后应激障碍的退伍军人在新奇任务期间，额叶部位的 P300 振幅显着增强，以响应分散注意力的刺激，但在三音古怪任务期间则不然。在这两项任务中，目标音调没有振幅差异。结论：数据表明，患有创伤后应激障碍的退伍军人表现出的 P300 反应与对新颖的分散注意力的刺激的增强定向反应一致。这一发现既与该疾病的临床表现相一致，也与创伤后应激障碍患者表现出对模糊或潜在威胁性刺激的信息处理偏见的理论观点一致。 (C) 2000 年生物精神病学协会。
Background: This study investigated attentional allocation in 39 Vietnam combat veterans, 25 with and 14 without posttraumatic stress disorder, assessing P300 amplitudes and latencies during both three-tone and novelty "oddball" tasks.Methods: The three-tone oddball task consisted of three stimuli: frequent tones (85%), rare target tones (75%), and rare distracter tones (75%). The novelty oddball task was identical to the three-tone task except that the rare distracter tones were replaced with nonrepeating novel sounds (75%).Results: Combat veterans with posttraumatic stress disorder showed significant P300 amplitude enhancements at frontal sites in response to distracting stimuli during the novelty but not during the three-tone oddball tasks. There were no amplitude differences in target tones during either task.Conclusions: The data suggest that combat veterans with posttraumatic stress disorder demonstrate P300 responses consistent with a heightened orientation response to novel, distracting stimuli. This finding is consistent both with the clinical presentation of the disorder and with theoretical notions that individuals with posttraumatic stress disorder demonstrate information-processing biases towards vague or potentially threatening stimuli. (C) 2000 Society of Biological Psychiatry.