Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum.
Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum.
复制标题
神经生长因子可防止大鼠纹状体中的 1 型单纯疱疹病毒神经毒性。
DOI：
10.1097/00001756-199404000-00035
复制
发表时间：
1994
期刊：
影响因子：
1.7
通讯作者：
Chiocca,EA
中科院分区：
文献类型：
--
作者：
Pakzaban,P;Chiocca,EA
为探讨神经生长因子（NGF）对单纯疱疹病毒1型（HSV-1）神经毒性的影响，将HSV-1直接注射到大鼠纹状体内，然后连续7天向脑内注入NGF或溶媒溶液。在1周时，NGF治疗的动物中HSV-1介导的脑组织破坏的平均体积显著小于溶媒治疗的动物。HSV-1的免疫组织化学染色证实，在主要注射部位和远处传播的次要部位存在携带病毒的细胞，NGF治疗的动物和溶剂治疗的动物之间的HSV-1分布没有显着差异。我们的结论是，神经生长因子的纹状体内输注局部保护HSV-1介导的神经溶解，但不影响HSV-1在大脑中的传播。
TO determine the effect of nerve growth factor (NGF) on the neurotoxicity of herpes simplex virus type 1 (HSV-1) in vivo, direct intrastriatal injection of HSV-1 in rats was followed by continuous intracerebral infusion of NGF or vehicle solution for 7 days. The mean volume of HSV-1-mediated brain tissue destruction in NGF-treated animals was significantly smaller than that in vehicle-treated animals at 1 week. Immunohistochemical staining for HSV-1 confirmed the presence of cells harboring the virus at the primary site of injection and at secondary sites of distant spread, with no significant difference in HSV-1 distribution between NGF-and vehicle-treated animals. We conclude that intrastriatal infusion of NGF locally protects against HSV-1-mediated neurolysis, but does not affect HSV-1 dissemination in the brain.