How do cells move along surfaces?
How do cells move along surfaces?
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DOI：
10.1016/0962-8924(93)90084-e
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发表时间：
1993-01-01
影响因子：
19
通讯作者：
Jacobson, Ken
中科院分区：
文献类型：
--
作者：
Lee, Juliet;Ishihara, Akira;Jacobson, Ken
细胞沿表面运动是一种复杂的现象，包括细胞与基质的黏附、细胞边缘的伸缩等几个相互关联的过程，其中肌动蛋白细胞骨架起着至关重要的作用。在过去的十年里，对细胞运动性的分子研究越来越详细，但仍然不知道分子事件是如何整合到细胞运动中的。分子研究现在开始与整个细胞如何运动的更全球化的概念联系在一起，这种结合的方法有望产生对细胞运动的新见解。
The movement of cells along surfaces is a complex phenomenon that consists of several interrelated processes, including cell-substratum adhesion, and extension and retraction of the cell edge, in which the actin cytoskeleton plays a crucial role. The past decade has seen increasingly detailed molecular-based investigations into cell motility, but it is still not known how molecular events are integrated to give cell movement. Molecular studies are now beginning to be linked to a more global concept of how whole cells move, and this combined approach promises to yield new insights into cell locomotion.